摘要
目的探究赛庚啶与布洛芬联用对以头晕眩晕为显著特征的急性期前庭性偏头痛的临床疗效。方法前瞻性选择2020年3月—2024年3月于济宁医学院附属单县中心医院神经内科确诊为前庭性偏头痛发作期的105例患者作为研究对象,运用随机数表法分为两组,观察组53例,采用赛庚啶联合布洛芬治疗方案;对照组52例,予以甲磺酸倍他司汀加布洛芬治疗。两组患者均持续用药3 d,其间详细记录头晕眩晕程度、持续时长,头痛程度、持续时长等数据,并进行统计学分析。结果治疗前,两组的前庭症状指数评分(VSI)评分、头晕眩晕持续时间比较,差异无统计学意义(P>0.05);治疗后,两组的VSI评分、头晕眩晕持续时间均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组的视觉模拟评分法(VAS)评分、头痛持续时间比较,差异无统计学意义(P>0.05);治疗后,两组的VAS评分、头痛持续时间均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论赛庚啶与布洛芬联合治疗能够显著降低患者眩晕程度、缩短眩晕及头痛的持续时间,具备临床应用价值。
Objective To explore the clinical eff ect of cyproheptadine combined with ibuprofen on acute vestibular migraine with dizziness and vertigo.Methods A total of 105 patients with vestibular migraine were prospectively selected from March 2020 to March 2024 in the Department of Neurology,Shan County Central Hospital,Jining Medical College.The patients were divided into two groups by random number table method.53 patients in the observation group were treated with cyprohepidine combined with ibuprofen.Control group 52 cases were treated with betahistine mesylate and ibuprofen.Patients in both groups continued to take medication for 3 days,during which the degree of dizziness,duration,degree of headache,duration and other data were recorded in detail,and statistical analysis was carried out.Results Before treatment,there was no diff erence in vestibular symptom index(VSI)score and duration of dizziness between the two groups(P>0.05).After treatment,the VSI score and duration of dizziness and vertigo in both groups were lower than before treatment,and the observation group was lower than the control group,with statistical signifi cance(P<0.05).Before treatment,there was no diff erence in visual analogue scale(VAS)score and headache duration between the two groups(P>0.05).After treatment,VAS scores and headache duration of both groups were lower than before treatment,and observation group was lower than control group,the diff erence was statistically signifi cant(P<0.05).There was no diff erence in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Combined treatment with cyprohepidine and ibuprofen can signifi cantly reduce the degree of vertigo and shorten the duration of vertigo and headache,which has clinical application value.
作者
鹿时刚
LU Shi-gang(Department of Neurology,Shanxian Central Hospital Affi liated to Jining Medical College,Heze Shandong,274300,China)
出处
《中华养生保健》
2025年第10期189-193,共5页
CHINESE HEALTH CARE
关键词
赛庚啶
布洛芬
头晕眩晕
前庭性偏头痛
不良反应
cyproheptadine
ibuprofen
dizziness
vertigo
vestibular migraine
adverse reaction
作者简介
鹿时刚(1978-),男,汉族,籍贯:山东省菏泽市,本科,副主任医师,研究方向:脑血管病、头晕眩晕;通讯作者:鹿时刚,E-mail:deer3@163.com。
