摘要
目的分析微小RNA(miR)-586、Toll样受体7(TLR7)表达对老年食管癌患者同步放化疗预后的预测价值。方法选取广元市中心医院2021年1月至2022年12月收治的100例老年食管癌患者为研究对象。所有患者均接受同步放化疗治疗。收集所有患者的一般资料(性别、年龄、临床分期等)和实验室资料(miR-586、TLR7),并对患者进行为期2年的随访,根据患者随访2年的生存情况分为生存组(n=75)和死亡组(n=25)。采用单因素分析老年食管癌患者同步放化疗生存预后的相关因素,采用Cox回归分析老年食管癌患者同步放化疗生存预后的独立危险因素。并绘制miR-586、TLR7不同表达水平患者的2年Kaplan-Meier生存曲线。结果单因素分析结果显示,年龄、miR-586、TLR7为老年食管癌患者同步放化疗生存预后的相关因素(P<0.05)。Cox回归分析结果显示,年龄、miR-586升高,TLR7降低为老年食管癌患者同步放化疗生存预后的独立危险因素(P<0.05)。生存曲线分析结果显示,miR-586高表达、TLR7低表达患者2年生存率低于miR-586低表达、TLR7高表达患者,差异有统计学意义(P<0.05)。结论年龄、miR-586、TLR7表达与老年食管癌患者同步放化疗生存预后有关,且miR-586高表达、TLR7低表达患者的2年生存率更低。
Objective To analyze the prognostic value of microrna(miR)⁃586 and Toll⁃like recep⁃tor 7(TLR7)in elderly patients with esophageal cancer undergoing concurrent chemoradiotherapy.Methods A total of 100 elderly patients with esophageal cancer admitted to the Guangyuan Central Hospital from January 2021 to December 2022 were selected as the research subjects.All patients received concurrent chemoradio⁃therapy.The general data(gender,age,clinical stage,etc.)and laboratory data(miR⁃586,TLR7)were col⁃lected for all patients,who were then followed up for 2 years.Based on the patientssurvival outcomes during the follow⁃up period,they were divided into a survival group(n=75)and a death group(n=25).Univariate analysis was used to analyze the related factors of survival prognosis in elderly patients with esophageal cancer treated with concurrent chemoradiotherapy.Cox regression was used to identify independent risk factors for sur⁃vival prognosis in this patient population.Kaplan⁃Meier survival curves for 2 years were plotted for patients with different expression levels of miR⁃586 and TLR7.Results The results of univariate analysis showed that age,miR⁃586 and TLR7 were significant factors for the survival prognosis of elderly patients with esophageal cancer undergoing concurrent chemoradiotherapy(P<0.05).Cox regression analysis showed that age increased miR⁃586,and decreased TLR7 were independent risk factors for the survival prognosis of elderly patients with esophageal cancer treated with concurrent chemoradiotherapy(P<0.05).Survival curve analysis indicated that the 2⁃year survival rate of patients with high miR⁃586 expression and low TLR7 expression was lower compared to patients with low miR⁃586 expression and high TLR7 expression(P<0.05).Conclusion Age,miR⁃586,and TLR7 expression are factors related to the survival prognosis of elderly patients with esophageal cancer undergo⁃ing concurrent chemoradiotherapy.Patients with high miR⁃586 expressions and low TLR7 tend to have a lower 2⁃year survival rate.
作者
蒋朝霞
李磊
李晓明
JIANG Zhaoxia;LI Lei;LI Xiaoming(School of Clinical Medicine,North Sichuan Medical University,Guangyuan,Sichuan,China,628000;Department of Thoracic Surgery,Guangyuan Central Hospital,Guangyuan,Sichuan,China,628000)
出处
《分子诊断与治疗杂志》
2025年第8期1425-1428,共4页
Journal of Molecular Diagnostics and Therapy
基金
四川省医学会医学科研青年创新课题(Q23015)。
作者简介
通信作者:李晓明,E⁃mail:156776052@qq.com。
