摘要
目的 探讨右美托咪定联合七氟烷对心肌缺血手术患者BDNF、S100B、cTnT水平及术后认知功能和心功能的影响。方法 选取漯河市中心医院2023年1月至2024年6月142例心肌缺血手术患者,随机分为试验组(七氟烷+右美托咪定)和对照组(七氟烷+安慰剂),比较两组术前后BDNF、S100B、cTnT、LVEF、CO、CV及MMSE评分。结果 两组手术时间及术中出血量比较差异无统计学意义(P>0.05);试验组术后6 h、12 h BDPN水平显著高于对照组,差异有统计学意义(P<0.05),S100B、cTnT水平显著低于对照组,差异有统计学意义(P<0.05);术后6 h、12 h试验组CO、CV、LVEF、MMSE评分均优于对照组,差异有统计学意义(P<0.05)。结论 右美托咪定联合七氟烷能改善心肌缺血手术患者术后认知及心功能,可能通过提高BDNF水平、降低S100B和cTnT水平发挥作用。
Objective To investigate the effect of dexmedetomidine combined with sevoflurane on the levels of NF,S100B,and cTnT in patients undergoing myocardial ischemia surgery and its effect on postop⁃erative cognitive function and cardiac function.Methods 142 cases of patients undergoing myocardial isch⁃emia surgery were randomly divided into the experimental group(sevoflurane dexmedetomidine)and the con⁃trol group(sevoflurane placebo).The levels of BDNF,S100B,cTnT,LVEF,CV,and MMSE scores were compared between the two groups before and after the operation.Results There was no significant difference in the operation time and intraoperative blood loss between the two groups(P>0.05).The BDNF levels at 6 and 12 hours after the operation in the experimental group were significantly higher than in the control group(P<0.05),and the S100B and cTnT levels were significantly lower than those in the control group(P<0.05).The CO,CV,LVEF,and MMSE scores at 6 and 12 hours after the operation in the experimental group were like those in the control group(P<0.05).Conclusion Dexmedetomidine combined with sevoflurane can enhance cognitive and cardiac function in patients undergoing myocardial ischemia surgery.This combination may work by increasing BDNF levels and decreasing S100B and TnT levels.
作者
崔魁
李永强
殷亚鹏
白娜
郎志斌
CUI Kui;LI Yongqiang;YIN Yapeng;BAI Na;LANG Zhibin(Anesthesia Department of Luohe Central Hospital,Luohe,Henan,China,462300)
出处
《分子诊断与治疗杂志》
2025年第8期1407-1409,1413,共4页
Journal of Molecular Diagnostics and Therapy
基金
河南省医学科技攻关计划联合共建项目(LHGJ20220124)。
关键词
右美托咪定
七氟烷
心肌缺血
脑源性神经营养因子
S100钙结合蛋白B
心肌损伤标志物
Dexmedetomidine
Sevoflurane
Myocardial ischemia
Brain⁃derived neurorophic fac⁃tor
S100 calcium⁃binding protein B
Biomarkers of myocardial injury
作者简介
通信作者:郎志斌,E⁃mail:dr.lang@zzu.edu.cn。
