摘要
膝骨关节炎(knee osteoarthritis,KOA)与骨质疏松症(osteoporosis,OP)“共病”是一种慢性进行性疾病,近年发病率较高。外泌体具有细胞间信使的作用,贯穿KOA与OP“共病”的发生发展。本文从现代医学和中医学筋、骨、肝肾相关理论认识KOA与OP“共病”,梳理外泌体对KOA与OP“共病”的间接调控作用,探讨中药基于外泌体从炎症反应、MAPK通路、骨重塑与软骨代谢及线粒体自噬等方面治疗KOA与OP“共病”的可能机制,为中药治疗KOA与OP“共病”提供新的思路。
Knee osteoarthritis(KOA)and osteoporosis(OP)“co-morbidity”is a chronic progressive disease,the incidence of which is higher in recent years.Exosomes have intercellular messenger functions,which play an important role in the development of KOA and OP“co-morbidity”.This article recognized the“co-morbidity”between KOA and OP from the perspective of modern medicine and the“tendon”,“bone”,“liver”and“kidney”in TCM theories,systematically reviewed the indirect regulation of KOA and OP“co-morbidity”through exosomes,and explored the possible mechanisms of exosome-based treatment of KOA and OP“co-morbidity”through Chinese materia medica in terms of inflammation,MAPK pathway,bone remodeling and cartilage metabolism,and mitochondrial autophagy,with the aim to investigate the possible mechanisms of KOA and OP“co-morbidity”,and provide new ideas for the treatment of KOA and OP“co-morbidity”.
作者
邹远超
尹润宇
杨浩宇
马常荣
刘爱峰
李远栋
ZOU Yuanchao;YIN Runyu;YANG Haoyu;MA Changrong;LIU Aifeng;LI Yuandong(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China;National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China)
出处
《中国中医药信息杂志》
2025年第9期186-191,共6页
Chinese Journal of Information on Traditional Chinese Medicine
基金
天津市中医中西医结合科研课题(2021105)
河北省中医药管理局科研计划项目(T2025087)
天津市高等学校研究生教育改革研究计划项目(TJYG020)
天津市教育工作重点调研课题(JYDY-20241036)。
关键词
膝骨关节炎
骨质疏松症
外泌体
中药
共病
综述
knee osteoarthritis
osteoporosis
exosome
Chinese materia medica
co-morbidity
review
作者简介
通讯作者:李远栋,E-mail:33724755@qq.com。
