摘要
脓毒症是一种由严重感染引起宿主功能紊乱的全身性炎症反应综合征,常累及多器官致功能衰竭,而脓毒症急性肺损伤是其最常见的并发症,其死亡率居高不下。尽管近年来对脓毒症急性肺损伤的研究不断深入,但其发病机制尚未十分明确,可能涉及炎症反应、氧化应激、遗传机制、细胞焦亡、线粒体自噬、铁死亡、凝血异常等。本文对脓毒症急性肺损伤发病机制研究进行综述,以期提高临床对该病的系统认识。
Sepsis is a systemic inflammatory response syndrome caused by severe infection leading to host dysfunction,often involving multiple organs and causing functional failure.Acute lung injury is the most common complication of sepsis,with high mortality.Although the research on acute lung injury in sepsis has been continuously deepened in recent years,its pathogenesis is not yet very clear.It may involve inflammatory responses,oxidative stress,genetic mechanisms,pyroptosis,mitochondrial autophagy,ferroptosis,abnormal coagulation,etc.This article reviews the research on the pathogenesis of acute lung injury in sepsis,with the aim of improving the systematic clinical understanding of this disease.
作者
王琴
余旭
李青颖
芦乙滨
WANG Qin;YU Xu;LI Qingying;LU Yibin(Department of Critical Care Medicine,Xinyang Central Hospital,Xinyang,Henan 464000,China)
出处
《中国临床研究》
2025年第8期1154-1157,共4页
Chinese Journal of Clinical Research
基金
信阳市重点研发与推广专项(20230013)。
关键词
脓毒症
急性肺损伤
发病机制
炎症反应
氧化应激
细胞焦亡
铁死亡
线粒体自噬
凝血功能
Sepsis
Acute lung injury
Pathogenesis
Inflammatory responses
Oxidative stress
Pyroptosis
Ferroptosis
Mitochondrial autophagy
Coagulation function
作者简介
通信作者:芦乙滨,E⁃mail:luyb6810@163.com。
