摘要
茯苓多糖是来源于多孔菌科真菌茯苓的干燥菌核、菌丝体和发酵液等药效物质,其具有抗肿瘤、抗炎、抗氧化和抗抑郁等生物活性。茯苓多糖临床上主要用于治疗恶性肿瘤、结肠炎以及抑郁症等疾病。随着对茯苓多糖的抗肿瘤机制深入研究,研究者发现其通过免疫调节、抑制肿瘤细胞增殖、抗血管生成和遗传调控等抗肿瘤作用,尤其在肝癌、肺癌以及乳腺癌等治疗中广泛应用。该文将拟茯苓多糖对抗肿瘤的最新作用机制进行全面、系统归纳总结,为茯苓多糖抗肿瘤作用的临床应用、新药开发提供基础资料和理论依据。
Poria cocos polysaccharide is a medicinal substance derived from dried sclerotium,mycelium and fermentation broth of Poria cocos.It exhibits various biological activities,including anti-tumor,anti-inflammatory,antioxidant and antidepressive effects.Poria cocos polysaccharide is mainly used in clinical practice to treat malignant tumors,colitis and depression and other diseases.With the in-depth study of the anti-tumor mechanism of Poria cocos polysaccharides,researchers have found that it exerts anti-tumor effects through immune regulation,inhibition of tumor cell proliferation,anti-angiogenesis and genetic regulation,and is widely used in the treatment of liver cancer,lung cancer and breast cancer.This article will comprehensively and systematically summarize the latest mechanism of action of Poria cocos polysaccharides against tumors,providing basic data and theoretical basis for the clinical application of the antitumor effect of Poria cocos polysaccharides and the development of new drugs.
作者
周明
刘敏
吕玉亮
ZHOU Ming;LIU Min;LV Yuliang(College of Integrated Traditional Chinese and Western Medicine,School of Traditional Chinese Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,Jiangsu Province,China;Guoyitang Outpatient Department,Nanjing University of Chinese Medicine,Nanjing 210029,Jiangsu Province,China;Nanxiang Hospital,Jiading District,Shanghai 201802,China)
出处
《世界临床药物》
2025年第7期720-723,共4页
World Clinical Drug
基金
江苏省自然科学基金(BK20210687)。
关键词
茯苓多糖
抗肿瘤
研究进展
Poria cocos polysaccharide
anti-tumor
research progress
作者简介
周明,主治医师,讲师,研究方向:中医药防治脾胃疾病机制研究。
