摘要
目的采用认知负荷理论指导的营养策略对糖尿病肾病血透患者炎症反应及营养改善作用的探讨。方法本研究采用回顾性方法,分析2022年1月—2024年9月期间建湖县人民医院收治的108例糖尿病肾病维持性血液透析患者的临床资料。依据所接受的干预方式不同,将患者分为研究组与对照组进行比较分析,每组54例。对照组接受常规饮食方案治疗,研究组接受认知负荷理论指导下的营养支持治疗。对比两组血糖水平[空腹血糖(fasting blood glucose,FBG)、餐后2 h血糖(2-hour postprandial blood glucose,2 hPBG)、糖化血红蛋白(glycated hemoglobin A1c,HbA1c)]、营养状况[血清前白蛋白(pre-albumin,PAB)、血清白蛋白(serum albumin,Alb)、转铁蛋白(transferrin,TRF)]、炎症因子[C反应蛋白(C-reactive protein,CRP)、白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)]的差异。结果治疗后,研究组FBG、2 hPBG、HbA1c水平较对照组有所降低,差异均有统计学意义(P均<0.05)。研究组PAB、Alb、TRF水平均高于对照组,差异均有统计学意义(P均<0.05)。研究组CRP、IL-6、TNF-α水平较对照组有所降低,差异均有统计学意义(P均<0.05)。结论借助认知负荷理论优化营养支持策略,能够在糖尿病肾病血透患者中起到稳定血糖、提升营养水平以及减轻炎症反应的积极作用。
Objective To explore the effect of nutritional strategy guided by cognitive load theory on inflammatory re-sponse and nutritional improvement in hemodialysis patients with diabetic nephropathy.Methods This study used a retrospective method to analyze the clinical data of 108 patients with diabetic nephropathy undergoing maintenance hemodialysis admitted to Jianhu People's Hospital from January 2022 to September 2024.According to the different intervention methods,the patients were divided into study group and control group for comparative analysis,with 54 cases in each group.The control group received conventional diet treatment,and the study group received nutritional support treatment under the guidance of cognitive load theory.The differences of blood glucose levels[fasting blood glucose(FBG),2-hour postprandial blood glucose(2 hPBG),glycated hemoglobin A1c(HbA1c)],nutritional status[prealbumin(PAB),serum albumin(Alb),transferrin(TRF)],inflammatory factors[C-reactive protein(CRP),interleu-kin-6(IL-6),tumor necrosis factor-α(TNF-α)]were compared between the two groups.Results After treatment,the levels of FBG,2 hPBG and HbA1c in the study group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The levels of PAB,Alb and TRF in the study group were higher than those in the control group,and the differences were statistically significant(all P<0.05).The levels of CRP,IL-6 and TNF-αin the study group were lower than those in the control group,and the differences were statistically significant(all P<0.05).Conclusion By optimizing the nutritional support strategy with the help of cognitive load theory,it can play a positive role in stabilizing blood glucose,improving nutritional level and reducing inflammatory response in hemodialy-sis patients with diabetic nephropathy.
作者
周建华
夏文亚
严钊
ZHOU Jianhua;XIA Wenya;YAN Zhao(Department of Nephrology,Jianhu People's Hospital,Jianhu 224700,Jiangsu,China)
出处
《糖尿病新世界》
2025年第13期6-10,共5页
Diabetes New World
基金
江苏医药职业学院盐城市卫生健康委员会校地协同创新研究项目(202490208)。
关键词
糖尿病肾病
维持性血液透析
认知负荷理论
Diabetic nephropathy
Maintenance hemodialysis
Cognitive load theory
作者简介
周建华(1990-),女,本科,主治医师,研究方向为糖尿病肾病;通信作者:严钊(1982-),男,本科,副主任医师,研究方向为糖尿病肾病,E-mail:jsyanzhao@outlook.com。
