摘要
目的研究经鼻高流量氧疗中供氧流量对上呼吸道气压分布的影响规律。方法采用1名成人男性CT图像重建上呼吸道三维模型,并与高流量鼻导管模型耦合,建立鼻导管-上呼吸道耦合的数值几何模型。采用3D打印技术将该上呼吸道三维模型制作为实体模型,结合头模、机械模拟肺和监测系统,构建体外实体仿真实验平台。分别通过流体力学数值计算模拟和实体仿真实验,测量不同供氧流量情况下上呼吸道典型位置处的气流压强。结果数值模拟仿真结果与实体仿真实验结果吻合良好;气道峰值压力和呼气末正压均随供氧流量增加呈二次函数形式升高;气压分布在喉部气道界面相对于鼻腔部截面更为均匀。结论本研究结果可为临床经鼻高流量氧疗中优化供氧流量设定及呼气末正压评估位置选择提供理论支持。
Objective To investigate the influence of oxygen supply flow rate in high-flow nasal cannula(HFNC)oxygen therapy on pressure distributions in the upper airway.Methods A three-dimensional(3D)model of the upper airway was reconstructed using CT images from an adult male,and then coupled with a high-flow nasal cannula model to establish a coupled model of the nasal cannula and the upper airway.Subsequently,a physical model of this upper airway,which was combined with a head model,artificial lungs,and a monitoring system was created by 3D printing technology to form a physical simulation platform in vitro.Computational and physical simulations were carried out respectively to determine the air pressure at typical locations in the upper airway under different oxygen supply flow rates.Results Pressures at typical upper airway locations obtained by computational and physical simulations turned out to be in good agreement;both peak inspirational pressure(PIP)and positive end-expiratory pressure(PEEP)increased quadratically with the increase of oxygen supply flow rate;and the air pressure distribution was more uniform in the laryngeal cross-section as compared to the nasal part of the upper airway.Conclusions This study may provide a theoretical support for optimization of the setting of oxygen suppy flow rate and the selection of PEEP effect assessment position in the clinical application of HFNC oxygen therapy.
作者
贾硕
王亚伟
陶春静
刘建军
刘加龙
樊瑜波
JIA Shuo;WANG Yawei;TAO Chunjing;LIU Jianjun;LIU Jialong;FAN Yubo(Beihang-Aeonmed Joint Laboratory,Beihang University,Beijing 100083,China;Beijing Aeonmed Co.,Ltd.,Beijing 100070,China)
出处
《医用生物力学》
北大核心
2025年第4期1027-1033,共7页
Journal of Medical Biomechanics
基金
北航-谊安联合实验室自设课题基金。
关键词
经鼻高流量氧疗
呼气末正压
计算流体力学
数值仿真
实体仿真
high-flow nasal cannula(HFNC)
oxygen therapy
positive end expiratory pressure(PEEP)
computational fluid dynamics
numerical simulation
physical simulation
作者简介
共同通信作者:樊瑜波,教授,E-mail:yubofan@buaa.edu.cn;共同通信作者:刘建军,高级工程师,E-mail:liujianjun@aeonmed.com。
