摘要
目的探究不同剂量阿司匹林联合硫酸镁治疗妊娠高血压(PIH)致胎儿生长受限(FGR)效果。方法选择2020年1月至2023年1月在我院治疗的PIH患者102例,应用随机数表法将其分为对照组(150mg阿司匹林联合硫酸镁)及观察组(100mg阿司匹林联合硫酸镁)各51例,对比两组脐血流指标[阻力指数(RI)、血流速度峰谷比(S/D)和脉动指数(PI)]、凝血指标[纤维蛋白原(FIB)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)]、血管内皮指标[一氧化氮(NO)、内皮素(ET-1)、血管内皮生长因子(VEGF)]、尿酸(UA)、胱抑素C(Cys)、基质金属蛋白酶-9(MMP-9)、妊娠结局。结果治疗后,两组脐血流指标均降低,观察组RI、S/D、PI低于对照组,差异有统计学意义(P<0.05)。治疗后,两组APTT、PT显著延长、FIB降低,对照组APTT、PT短于对照组、FIB高于对照组,差异有统计学意义(P<0.05)。治疗后,两组NO、VEGF升高、ET-1降低,观察组NO、ET-1高于对照组、ET-1低于对照组,差异有统计学意义(P<0.05)。治疗后,两组UA、Cys、MMP-9降低,观察组UA、Cys、MMP-9低于对照组,差异有统计学意义(P<0.05)。观察组分娩时胎龄长于对照组、新生儿体质量高于对照组、产后出血发生率低于对照组,差异有统计学意义(P<0.05);两组新生儿窒息发生率差异无统计学意义(P>0.05)。结论PIH致FGR患者接受100mg阿司匹林联合硫酸镁治疗,可改善脐血流量、凝血指标,调节血管内皮功能,下调UA、Cys、MMP-9水平,延长妊娠周期,促进胎儿生长。
Objective to investigate the effect of different doses of aspirin combined with magnesium sulfate in the treatment of pregnancy hypertension(PIH)to fetal growth restriction(FGR).Methods 102 patients with PIH treated in our hospital from January 2020 to January 2023 were selected and divided into 51 cases each in the control group(150 mg aspirin combined with magnesium sulfate)and the observation group(100 mg aspirin combined with magnesium sulfate)by applying the random number table method,and the umbilical cord blood flow indexes[resistance index(RI),peak-to-valley ratio of blood flow rate(S/D)and pulsatility index(PI)],coagulation indexes[fibrinogenetic index(FGR)],and coagulation indexes[fibrinogenetic index(FI)]were compared between the two groups.,coagulation indexes[fibrinogen(FIB),prothrombin time(PT),activated partial thromboplastin time(APTT)],vascular endothelial indexes[nitric oxide(NO),endothelin(ET-1),vascular endothelial growth factor(VEGF)],uric acid(UA),cystatin C(Cys),matrix metalloproteinase-9(MMP-9),pregnancy outcome.Results After treatment,umbilical blood flow indexes were reduced in both groups,and RI,S/D,and PI were lower in the observation group than in the control group,with statistically significant differences(P<0.05).After treatment,APTT and PT were significantly prolonged and FIB was reduced in both groups,and APTT and PT were shorter and FIB was higher than those in the control group,with statistically significant differences(P<0.05).After treatment,NO and VEGF were elevated and ET-1 was reduced in both groups,and NO and ET-1 were higher and ET-1 was lower in the observation group than in the control group,and the difference was statistically significant(P<0.05).After treatment,UA,Cys and MMP-9 decreased in both groups,and UA,Cys and MMP-9 were lower in the observation group than in the control group,and the difference was statistically significant(P<0.05).In the observation group,gestational age at delivery was longer than that of the control group,neonatal body mass was higher than that of the control group,and the incidence of postpartum haemorrhage was lower than that of the control group,with statistically significant differences(P<0.05);the difference in the incidence of asphyxia of newborns between the two groups was not statistically significant(P>0.05).Conclusion Patients with PIH to FGR treated with 100mg aspirin combined with magnesium sulfate can improve umbilical blood flow,coagulation indexes,regulate vascular endothelial function,down-regulate the levels of UA,Cys,and MMP-9,prolong the gestation cycle,and promote the growth of fetus.
作者
刘慧云
叶晶晶
LIU Hui-yun;YE Jing-jing(Women and Infants Hospital of Zhengzhou,Zhengzhou 450000,Henan Province,China)
出处
《罕少疾病杂志》
2025年第8期153-156,共4页
Journal of Rare and Uncommon Diseases
关键词
不同剂量阿司匹林
硫酸镁
妊娠期高血压
胎儿生长受限
血清尿酸
胱抑素C
Different Doses of Aspirin
Magnesium Sulfate
Hypertension In pregnancy
Fetal Growth Restriction
Serum Uric Acid
Cystatin C
作者简介
第一作者/通讯作者:刘慧云,女,主治医师,主要研究方向:围产医学。E-mail:lhy123liuhuiyun@163.com。
