摘要
结肠炎是常发生于青壮年的慢性特异性炎症性病变,发病机制复杂。氧化苦参碱可通过减轻炎症反应、激活自噬通路、抑制铁死亡、调节肠道菌群结构、促进新生血管形成、保护肠道黏膜屏障功能发挥治疗结肠炎的作用。总结了氧化苦参碱治疗结肠炎的药理作用研究进展,为氧化苦参碱的临床应用提供参考。
Colitis is a chronic,specific inflammatory disease that often occurs in young adults,with a complex pathogenesis.Oxymatrine can treat colitis by reducing inflammation,activating autophagy pathways,inhibiting ferroptosis,regulating intestinal microbiota structure,promoting neovascularization,and protecting intestinal mucosal barrier function.This article summarizes the pharmacological research progress of oxymatrine in treatment of colitis,providing reference for the clinical application of oxymatrine.
作者
钟昌辉
卿松
夏红
杨春燕
ZHONG Changhui;QING Song;XIA Hong;YANG Chunyan(Department of Emergency,the People's Hospital of Dazu,Chongqing,Chongqing 402360,China;Department of General Surgery,the People's Hospital of Dazu,Chongqing,Chongqing 402360,China;Department of Infectious Diseases,the People's Hospital of Dazu,Chongqing,Chongqing 402360,China)
出处
《现代药物与临床》
2025年第7期1835-1840,共6页
Drugs & Clinic
基金
重庆市科卫联合医学科研项目(2019ZDXM042)。
关键词
氧化苦参碱
结肠炎
炎症反应
自噬通路
铁死亡
肠道菌群结构
新生血管形成
肠道黏膜屏障功能
oxymatrine
colitis
inflammation
autophagy pathway
ferroptosis
intestinal microbiota structure
neovascularization
intestinalmucosalbarrierfunction
作者简介
钟昌辉(1990—),女,主管护师,本科,研究方向为急诊护理。E-mail:763097363@qq.com;通信作者:杨春燕(1993—),女,本科,主管护师,研究方向为普外科护理。E-mail:951024149@q.com。
