摘要
目的分析应激诱导蛋白2(SESN2)、网膜素-1(omentin-1)在急性脑出血(ACH)中的表达情况及临床意义。方法选取91例ACH患者的病例资料,依据发病后神经功能缺损程度不同将其分为重度组21例、中度组35例和轻度组35例。分析SESN2、omentin-1与ACH患者神经炎症指标、神经功能指标的相关性及对不良预后的预测效能。结果重度组的SESN2水平分别高于中度组和轻度组,omentin-1水平分别低于中度组和轻度组,差异均具有统计学意义(P<0.05)。重度组的白细胞计数(WBC)、中性粒细胞计数(Neu)、神经元特异性烯醇化酶(NSE)、中枢神经特异蛋白(S100β)的测得值均分别高于中度组和轻度组(P<0.05)。SESN2与WBC、Neu、NSE、S100β均呈正相关(P<0.05)。omentin-1与WBC、Neu、NSE、S100β均呈负相关(P<0.05)。预后不良组的SESN2表达水平高于预后良好组,omentin-1水平低于预后良好组(P<0.05)。SESN2、omentin-1联合检测对ACH患者不良预后的预测灵敏度、特异度均高于SESN2、omentin-1的单独检测。结论联合检测SESN2、omentin-1能实现对患者不良预后的早期预测。
Objective To analyze the expressions of stress-induced protein 2(SESN2)and omentin-1 in the patients with acute cerebral hemorrhage(ACH)and explore their clinical significance.Methods The case data of 91 ACH patients were selected.According to the different degrees of neurological deficits after the onset,the patients were divided into the severe group(21 cases),the moderate group(35 cases),and the mild group(35 cases).The correlation between the levels of SESN2 and omentin-1,neuroinflammatory indicators and neuvological functional indicators in ACH patients was analyzed.The predictive efficacy of SESN2 and omega-3 levels for poor prognosis in ACH patients was analyzed.Results The level of SESN2 in the severe group was higher than that in the moderate group or the mild group,statistically showing a statistically significant difference(P<0.05).The level of Omentin-1 in the severe group was lower than that in the moderate group or the mild group(P<0.05).The white blood cell count(WBC),neutrophil count(Neu),neuron specific enolase(NSE),and central nervous system specific protein(S100β)in the severe group were higher than those in the moderate group,or the mild group(P<0.05).The level of SESN2 was positively correlated with the levels of WBC,Neu,NSE,and S100β(P<0.05).The level of omentin-1 was negatively correlated with the levels of WBC,Neu,NSE,and S100β(P<0.05).The level of SESN2 in the poor prognosis group was higher than that in the good prognosis group,and the level of omentin-1 in the poor prognosis group was lower than that in the good prognosis group(P<0.05).The combined detection of SESN2 and omentin-1 had higher sensitivity and specificity in predicting poor prognosis in ACH patients than the detection of SESN2 and omentin-1 alone.Conclusion The combined detection of SESN2 and Omentin-1 achieves the early prediction of adverse prognosis in ACH patients.
作者
张瑞
胡小丹
时阳阳
ZHANG Rui;HU Xiaodan;SHI Yangyang(Xinyang 154 Hospital,Xinyang 464000,China)
出处
《华夏医学》
2025年第4期114-119,共6页
Acta Medicinae Sinica
基金
河南省医学科技攻关项目(LHGJ20201215)。
关键词
急性脑出血
应激诱导蛋白2
网膜素-1
神经功能缺损
不良预后
acute cerebral hemorrhage
stress inducible protein 2
omectin-1
neurological dysfunction
poor prognosis
作者简介
第一作者:张瑞,本科,主治医师,研究方向为脑出血,zhangrui2537@126.com。
