摘要
目的分析急性白血病(acute leukemia,AL)患者化疗后肺部感染(pulmonary infection,PI)的影响因素。方法回顾性分析2023年8月—2024年8月112例AL患者的临床资料,将发生PI患者纳入观察组,未发生PI者纳入对照组,对比两组患者一般人口学资料及临床实验室指标,分析AL患者化疗后PI影响因素,并提出针对性干预对策。结果112例AL患者中34例发生PI,发生率为30.36%,未发生PI共有78例,占比69.64%;观察组吸烟、预防性使用抗生素、血小板水平、白蛋白水平、降钙素原与对照组相比较存在显著差异(P<0.05);观察组血小板水平、白蛋白水平明显低于对照组(P<0.05);Logistic回归分析示,吸烟、预防性使用抗生素、血小板水平、白蛋白、降钙素原是影响患者PI发生的独立因素。结论AL患者极易发生PI,且与血小板水平、白蛋白、吸烟、降钙素原存在密切联系,因此需制定针对性干预对策。
Objective To analyze the influencing factors of pulmonary infection(PI)after chemotherapy in patients with acute leukemia(AL).Methods The clinical data of 112 AL patients from August 2023 to August 2024 were analyzed retrospectively,grouped according to whether PI occurred or not,patients with PI were included in the observation group,and those without PI were included in the control group,and the general demographic data and clinical laboratory indexes of the two groups of patients were compared,to identify factors infuencing PI after chemotheray in AL patients and propose targeted intervention strategies.Results Among 112 AL patients,34 cases of PI occurred,with an incidence rate of 30.36%,and a total of 78 cases of PI did not occur,accounting for 69.64%;there was a significant difference between the smoking,prophylactic use of antibiotics,platelet level,albumin level,procalcitoninogen in the observation group,and in the control group(P<0.05);Specifically,platelet count and albumin level in the observation group were significantly lower than those in the control group(P<0.05).Logistic regression equation identified smoking,prophylactic use of antibiotics,platelet level,albumin,and calcitoninogen were the factors affecting the occurrence of PI in patients.
作者
蔡颖
张静
粱婷婷
CAI Ying;ZHANG Jing;LIANG Tingting(Ninth Ward of Hematology,Henan Cancer Hospital,Zhengzhou 450000,China)
出处
《济宁医学院学报》
2025年第4期331-334,共4页
Journal of Jining Medical University
基金
河南省科学技术厅项目(232102310201)。
关键词
急性白血病
肺部感染
影响因素
Acute leukemia
Pulmonary infection
Influencing factor
