摘要
目的:分析肺炎支原体肺炎(Mycoplasma pneumoniae pneumonia,MPP)患儿发生慢性咳嗽的临床危险因素,探讨其预测指标。方法:选取2023年9月—2024年3月在北京市中关村医院儿科确诊MPP的患儿180例,根据慢性咳嗽发生情况分为病例组(n=52)和对照组(n=128)。回顾性收集两组的一般资料、症状体征、影像学及实验室指标,采用logistic回归分析发生慢性咳嗽的影响因素,进一步通过ROC曲线评价CRP、中性粒细胞/淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)单独及联合检测对慢性咳嗽发生的预测效能。结果:在180例MPP患儿中有52例发生慢性咳嗽,发生率为28.9%。病例组被动吸烟史、慢性咳嗽病史、过敏性疾病史、发热时间≥7 d的患儿占比及NLR、CRP水平均高于对照组,差异有统计学意义(P<0.05);logistic回归分析显示,过敏性疾病史、发热时间≥7 d、NLR及CRP是患儿发生慢性咳嗽的独立危险因素(P<0.05)。ROC曲线分析显示,NLR、CRP单独及联合检测均可预测慢性咳嗽的发生,其AUC分别为0.720、0.866、0.892。结论:NLR、CRP单独及联合检测对患儿发生慢性咳嗽具有较好的临床预测价值,以联合检测的预测效能最高,可用于疾病早期筛选慢性咳嗽高风险患儿。
Objective:To analyze the clinical risk factors of chronic cough in children with Mycoplasma pneumoniae pneumonia(MPP)and explore its predictive indicators.Method:A total of 180 children diagnosed with MPP in the Pediatrics Department of Beijing Zhongguancun Hospital from September 2023 to March 2024 were selected and divided into the case group(n=52)and the control group(n=128)according to the occurrence of chronic cough.The general information,symptoms and signs,imaging and laboratory indicators of the two groups were retrospectively collected.logistic regression was used to analyze the influencing factors of chronic cough.Further,the predictive efficacy of CRP and neutrophil to lymphocyte ratio(NLR)alone and in combination for the occurrence of chronic cough were evaluated by ROC curve.Result:Among 180 children with MPP,52 cases developed chronic cough,with an incidence rate of 28.9%.The proportion of passive smoking history,chronic cough history,allergic disease history,duration of fever≥7 days,and NLR,CRP levels in case group were higher than those in control group,the differences were statistically significant(P<0.05).logistic regression analysis showed that history of allergic diseases,duration of fever≥7 days,NLR and CRP were independent risk factors for chronic cough in children(P<0.05).ROC curve analysis indicated that NLR,CRP and their combined detection could all predict the occurrence of chronic cough,with AUC of 0.720,0.866 and 0.892,respectively.Conclusion:The individual and combined detection of NLR and CRP have good clinical predictive value for the occurrence of chronic cough in children,the combined detection has the highest predictive efficacy and can be used for the early screening of children at high risk of chronic cough.
作者
刘向梅
屈晓
李鸿雁
王卉
LIU Xiangmei;QU Xiao;LI Hongyan;WANG Hui(Department of Pediatrics,Beijing Zhongguancun Hospital,Beijing 100190,China;不详)
出处
《中国医学创新》
2025年第23期140-144,共5页
Medical Innovation of China
作者简介
通信作者:刘向梅。
