摘要
目的:研究小青龙汤加减对痰浊壅肺证慢性阻塞性肺疾病急性加重期(AECOPD)患者中医证候积分、血气分析、炎症指标的影响。方法:选取2019年12月—2021年5月于福建中医药大学附属第三人民医院接受住院治疗的确诊为AECOPD且中医辨证为痰浊壅肺证的70例患者。70例患者以随机数字表法分为两组。对照组(n=35)接受规范基础西医治疗,观察组(n=35)给予规范基础西医治疗联合小青龙汤加减的中西医结合治疗。对两组中医证候积分、血气分析指标、炎症指标进行比较。结果:与治疗前相比,治疗7 d后两组咳痰、胸闷、咳嗽及喘息积分显著改善,且观察组改善明显优于对照组(P<0.05)。治疗7 d后,两组PaCO_(2)、PaO_(2)与治疗前相比显著好转,且观察组上述两项指标优于对照组(P<0.05)。治疗7 d后,两组降钙素原(PCT)、CRP与治疗前相比明显下降,且观察组优于对照组(P<0.05)。结论:小青龙汤加减治疗痰浊壅肺证AECOPD的效果确切,可有效减轻炎症反应,改善临床症状和血气分析指标。
Objective:To study the effects of modified Xiaoqinglong Decoction on TCM syndromes scores,blood gas analysis and infection indexes of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with syndrome of phlegm-turbid accumulation in the lung.Method:A total of 70 patients diagnosed with AECOPD and traditional Chinese medicine dialectized as phlegm-turbid accumulation in the lung who were hospitalized in the Third Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine from December 2019 to May 2021 were selected.The 70 patients were divided into two groups by the random number table method.The control group(n=35)received standardized basic western medicine treatment,the observation group(n=35)was given integrated traditional Chinese and Western medicine treatment of standardized basic western medicine treatment combined with modified Xiaoqinglong Decoction.The TCM syndrome scores,blood gas analysis indicators and inflammatory indicators of the two groups were compared.Result:Compared with before treatment,the scores of expectoration,chest tightness,cough,and wheezing in both groups were significantly improved after 7 days of treatment,and the improvement of the observation group were significantly better than those in the control group(P<0.05).After 7 days of treatment,PaCO_(2) and PaO_(2) in both groups improved significantly compared with those before treatment,and the above two indexes in the observation group were better than those in the control group(P<0.05).After 7 days of treatment,procalcitonin(PCT)and CRP in both groups decreased significantly compared with those before treatment,and the observation group was better than the control group(P<0.05).Conclusion:The modified Xiaoqinglong Decoction has a definite effect in the treatment of AECOPD with syndrome of phlegm-turbid accumulation in the lung.It can effectively reduce the inflammatory response,improve clinical symptoms and blood gas analysis indexes.
作者
刘宏波
王庆
安志鹏
方潇婷
张建生
LIU Hongbo;WANG Qing;AN Zhipeng;FANG Xiaoting;ZHANG Jiansheng(Department of Intensive Care Medicine,the Third Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine,Fuzhou 350100,China;不详)
出处
《中国医学创新》
2025年第22期5-9,共5页
Medical Innovation of China
基金
福建中医药大学校管临床专项资助项目(XB2019058)。
关键词
小青龙汤加减
慢性阻塞性肺疾病急性加重期
痰浊壅肺证
Modified Xiaoqinglong Decoction
Acute exacerbation of chronic obstructive pulmonary disease
Syndrome of phlegm-turbid accumulation in the lung
作者简介
通信作者:刘宏波。
