摘要
干燥综合征(SS)是以眼干、口干为主要临床表现的一种自身免疫性疾病,发病机制复杂,现有治疗方法的临床疗效仍显不足。水通道蛋白5(AQP5)作为一种特异性跨膜转运水分子的蛋白,可加速水分子的转运,维持细胞内外水的平衡,其表达水平与SS的发生发展密切相关。近年来研究表明,中医药可通过调控AQP5的表达改善SS患者症状,展现出良好的治疗潜力。本文系统综述AQP5在SS发病中的作用机制,并归纳基于AQP5调控的中药有效成分、复方及中成药治疗SS的研究进展,总结治疗方案,以期为SS的临床治疗提供新思路。
Sjögren's syndrome(SS)is an autoimmune disease characterized by dry eyes and dry mouth as primary clinical manifestations.Its pathogenesis is complex,and the clinical efficacy of existing treatments remains insufficient.Aquaporin 5(AQP5),as a protein specifically transporting water molecules across membranes,accelerates water molecule transport and maintains intracellular-extracellular water balance.Its expression level is closely related to the occurrence and progression of SS.Recent studies indicate that Traditional Chinese Medicine(TCM)can improve SS symptoms by regulating AQP5 expression,demonstrating substantial therapeutic potential.This article systematically reviews the mechanism of AQP5 in SS pathogenesis,summarizes research advances in active ingredients of TCM,Chinese herbal compound formulas,and Chinese patent drugs for treating SS based on AQP5 regulation,and consolidates treatment regimens,aiming to provide new insights for the clinical management of SS.
作者
韩其茂
陈璐
朱佳奇
李如
张皓然
曹娟
豆一凡
高丽娟
Han Qimao;Chen Lu;Zhu Jiaqi;Li Ru;Zhang Haoran;Cao Juan;Dou Yifan;Gao Lijuan(Department of Rheumatology,The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China;The Second Department of Gynecology,The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China;Heilongjiang University of Chinese Medicine,Harbin 150040,China)
出处
《保健医学研究与实践》
2025年第5期147-156,共10页
Health Medicine Research and Practice
基金
黑龙江省中医药科研项目(ZHY2023-166)
黑龙江省经济社会发展重点研究课题(基地专项)(24452)
黑龙江中医药大学科研基金项目(2019MS08)。
关键词
干燥综合征
中药有效成分
中药复方
中成药
水通道蛋白5
发病机制
Sjögren's syndrome
Active ingredients of TCM
Chinese herbal compound formulas
Chinese patent drug
Aquaporin 5
Pathogenesis
作者简介
第一作者:韩其茂,E-mail:hanqimaoweifang@163.com;通信作者:高丽娟,E-mail:sinogaoli@163.com。
