摘要
目的探究CA199、CA125、CA153、AFP、CEA及CTC对转移性乳腺癌的预测价值。方法收集136例乳腺癌患者临床资料进行回顾性分析。依照患者转移情况分为转移组(n=56例)和非转移组(n=80例)。比较转移组和非转移组一般资料、CA199、CA125、CA153、AFP、CEA、CTC。采用受试者操作特征曲线下面积(AUC)评估CA199、CA125、CA153、AFP、CEA及CTC对转移性乳腺癌的预测价值。结果转移组与非转移组患者年龄、体质量指数、文化程度、病理类型、发病部位比较,差异无统计学意义(P>0.05),转移组CA199、CA125、CA153、AFP、CEA、CTC均高于非转移组(P均<0.05)。CA199、CA125、CA153、AFP、CEA、CTC对转移性乳腺癌均有良好的预测价值,AUC分别为0.694、0.718、0.691、0.612、0.913、0.683,六者联合预测效能最佳,AUC为0.961,灵敏度、特异度较高。结论CA199、CA125、CA153、AFP、CEA、CTC对转移性乳腺癌均有良好的预测价值,但其联合预测效能最佳,可将其作为临床上转移性乳腺癌的预测因子,为转移性乳腺癌的防治提供依据。
Objective To investigate the predictive value of CA199,CA125,CA153,AFP,CEA and CTC in metastatic breast cancer.Methods The clinical data of 136 patients with breast cancer were collected for retrospective analysis.According to the metastasis of the patients,they were divided into the metastasis group(n=56 cases)and the non-metastasis group(n=80 cases).The general information,CA199,CA125,CA153,AFP,CEA and CTC were compared between the metastatic group and the non-metastatic group.The area under the receiver operating characteristic curve(AUC)was used to evaluate the predictive value of CA199,CA125,CA153,AFP,CEA and CTC for metastatic breast cancer.Results There was no statistically significant difference in age,body mass index,educational level,pathological type and lesion site between the metastasis group and the non-metastasis group(P>0.05).The levels of CA199,CA125,CA153,AFP,CEA and CTC in the metastasis group were all higher than those in the non-metastasis group(all P<0.05).CA199,CA125,CA153,AFP,CEA and CTC have good predictive value for metastatic breast cancer,with AUCs of 0.694,0.718,0.691,0.612,0.913 and 0.683 respectively.The combined predictive efficacy of the six is the best,with an AUC of 0.961 and high sensitivity and specificity.Conclusion CA199,CA125,CA153,AFP,CEA and CTC all have good predictive value for metastatic breast cancer.However,their combined predictive efficacy is the best.They can be used as predictors of metastatic breast cancer in clinical practice,providing a basis for the prevention and treatment of metastatic breast cancer.
作者
尚建华
侯毅
李振宇
赵艳
韩保卫
SHANG Jianhua;HOU Yi;LI Zhenyu(Luoyang Maternal and Child Health Hospital,Luoyang,471000)
出处
《实用癌症杂志》
2025年第8期1261-1264,共4页
The Practical Journal of Cancer
基金
河南省医学科技攻关联合共建项目(编号:LHGT202209-66)。
作者简介
通讯作者:韩保卫。
