摘要
目的:通过Meta分析对穴位注射治疗顽固性面瘫的疗效及安全性进行系统评价。方法:计算机检索万方、中国知网、维普、SinoMed、PubMed、Cochrane Library、Embase数据库中自建库至2024年7月9日以来穴位注射治疗顽固性面瘫的随机对照试验,根据纳排标准筛选文献并获取目标信息,在Cochrane偏倚风险评估手册基础上对纳入的文献进行质量评价,运用Rev-man 5.4软件对纳入研究的总有效率、愈显率、House-Brackmann面神经功能分级评价(H-B量表)进行Meta分析。结果:共纳入文献10篇,涉及顽固性面瘫患者645例。Meta分析结果显示,穴位注射治疗顽固性面瘫在临床总有效率[OR=4.42,95%CI(2.55,7.67),P<0.00001]、愈显率[OR=3.84,95%CI(2.64,5.58),P<0.00001]、H-B量表评分[MD=-0.87,95%CI(-1.38,-0.36),P=0.0008]方面均优于对照组。结论:穴位注射疗法治疗顽固性面瘫临床效果显著,安全性高。
Objective:To systematically evaluate the therapeutic effect and safety of acupoint injection in treating refractory facial paralysis through a Meta-analysis.Methods:Randomized controlled trials(RCTs)on acupoint injection for refractory facial paralysis were searched in Wanfang,CNKI,VIP,SinoMed,PubMed,Cochrane Library,and Embase from their establishment days to July 9,2024.Literature was screened based on inclusion and exclusion criteria,and target data were extracted.The quality of included studies was assessed using the Cochrane Risk of Bias Tool.Rev-Man 5.4 software was used for Meta-analysis of total effective rate,marked recovery rate,and House-Brackmann Facial Nerve Function Grading Scale(H-B Scale)scores.Results:Ten studies involving 645 patients with refractory facial paralysis were included.The Meta-analysis showed that acupoint injection significantly outperformed the control group in clinical outcomes:total effective rate[OR=4.42,95%CI(2.55,7.67),P<0.00001],marked recovery rate[OR=3.84,95%CI(2.64,5.58),P<0.00001],and H-B Scale scores[MD=-0.87,95%CI(-1.38,-0.36),P=0.0008].Conclusion:Acupoint injection demonstrates significant clinical effect and high safety in treating refractory facial paralysis.
作者
沈悦
李庆琳
王晨洋
熊晓婉
方晋元
皮敏
SHEN Yue;LI Qinglin;WANG Chenyang;XIONG Xiaowan;FANG Jinyuan;PI Min(The Fourth Clinical Medical School of Guangzhou University of Chinese Medicine,Shenzhen Guangdong 518033,China;Shenzhen Traditional Chinese Medicine Hospital,Shenzhen Guangdong 518033,China)
出处
《新中医》
2025年第15期157-163,共7页
New Chinese Medicine
基金
“三名工程”中国中医科学院刘保延学部委员中医针灸临床评价方法创新与应用团队项目(SZZYSM202311002)。
关键词
顽固性面瘫
穴位注射
随机对照试验
安全性
META分析
Refractory facial paralysis
Acupoint injection
Randomized controlled trials
Safety
Meta-analysis
作者简介
沈悦(1998-),女,硕士研究生,E-mail:syysdyx@163.com;通信作者:皮敏(1970-),男,主任中医师,E-mail:853109135@qq.com。
