摘要
目的探讨二丹红藤败酱汤加减联合针刺治疗气滞血瘀型盆腔炎性疾病后遗症(sequelae of pelvic inflammatory disease,SPID)患者疗效及对患者炎症指标和血液流变学影响。方法选择该院2021年1月—2024年6月就诊的SPID患者50例,依据随机数字表法分为观察组25例与对照组25例。对照组患者采取常规治疗,观察组在对照组基础上采用二丹红藤败酱汤加减联合针刺治疗,两组疗程均为21 d。比较两组治疗疗效,治疗前后中医证候积分,盆腔积液量,炎症指标和凝血指标变化及不良反应。结果观察组总有效率高于对照组(P<0.05)。治疗前,两组SPID患者腰骶痛、下腹痛和带下多积分相比差异无统计学意义(P>0.05);治疗后,两组SPID患者腰骶痛、下腹痛和带下多积分相比于治疗前降低(P<0.05);相比于对照组,观察组治疗后腰骶痛、下腹痛和带下多积分下降更明显(P<0.05)。治疗前,两组SPID患者盆腔积液量相比差异无统计学意义(P>0.05);治疗后,两组SPID患者盆腔积液量相比于治疗前降低(P<0.05);相比于对照组,观察组治疗后盆腔积液量下降更明显(P<0.05)。治疗前,两组SPID患者白细胞(WBC)、C-反应蛋白(CRP)和中性粒细胞百分比(NEUT%)水平相比差异无统计学意义(P>0.05);治疗后,两组SPID患者WBC、CRP和NEUT%水平相比于治疗前降低(P<0.05);相比于对照组,观察组治疗后WBC、CRP和NEUT%水平下降更明显(P<0.05)。治疗前,两组SPID患者D-二聚体(D-D)、凝血酶原时间(PT)和纤维蛋白原(Fib)水平相比差异无统计学意义(P>0.05);治疗后,两组SPID患者D-D、PT和Fib水平相比于治疗前降低(P<0.05);相比于对照组,观察组治疗后D-D、PT和Fib水平下降更明显(P<0.05)。结论二丹红藤败酱汤加减联合针刺治疗气滞血瘀型SPID患者疗效良好,且可减轻炎症指标及改善凝血功能,值得临床借鉴。
Objective To explore the therapeutic effect of modified Erdan Hongteng Baijiang Decoction(二丹红藤败酱汤)combined with acupuncture on patients with sequelae of pelvic inflammatory disease(SPID)of Qi stagnation and blood stasis syndrome,and its impact on inflammatory indicators and coagulation index in patients.Methods 50 SPID patients from our hospital from January 2023 to June 2024 divided observation group of 25 cases and a control group of 25 cases.The control group patients received conventional treatment,while the observation group received modified Erdan Hongteng Baijiang Decoction combined with acupuncture treatment basis of control group.The treatment course for two groups was 21 days.Compare the therapeutic effects of two groups of treatments;Before and after treatment,there were changes in traditional Chinese medicine syndrome scores,pelvic fluid volume and inflammatory mass size,inflammatory indicators,and hemorheology;and the situation of adverse reactions.Results The observation group effective rate was higher control group(P<0.05).Before treatment,two groups of SPID patients in terms of lumbosacral pain,lower abdominal pain,and multiple scores under the belt no significant difference(P>0.05);after treatment,two groups of SPID patients showed a decrease in lumbosacral pain,lower abdominal pain,and multiple scores under the belt compared to before treatment(P<0.05);compared with the control group,the observation group showed a more significant decrease in lumbosacral pain,lower abdominal pain,and multiple scores under the belt after treatment(P<0.05).Before treatment,two groups of SPID patients amount of pelvic fluid accumulation no significant difference(P>0.05);after treatment,two groups amount of pelvic fluid accumulation of SPID patients decreased compared to before treatment(P<0.05);compared with the control group,the observation group showed a more significant decrease in pelvic fluid volume after treatment(P<0.05).Before treatment,two groups of SPID patients levels of WBC,CRP,and NEUT%no significant difference(P>0.05);after treatment,the levels of WBC,CRP,and NEUT%in two groups of SPID patients decreased compared to before treatment(P<0.05);compared with the control group,the observation group showed a more significant decrease in WBC,CRP,and NEUT%levels after treatment(P<0.05).Before treatment,two groups of SPID patients levels of D-D,PT,and Fib no significant difference(P>0.05);after treatment,the levels of D-D,PT,and Fib in both groups of SPID patients decreased compared to before treatment(P<0.05);compared with the control group,the observation group showed a more significant decrease in D-D,PT,and Fib levels after treatment(P<0.05).The observation group incidence of adverse reactions was lower control group(P<0.05).Conclusion The combination of modified Erdan Hongteng Baijiang Decoction and acupuncture has a good therapeutic effect on SPID patients with Qi stagnation and blood stasis syndrome,and can reduce inflammatory indicators and improve coagulation function,which is worthy of clinical reference.
作者
柯琴
王莹倩
操丽
王芬
姚锐
刘特
KE Qin;WANG Yingqian;CAO Li;WANG Fen;YAO Rui;LIU Te(Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Anhui 230001,Hefei,China;Shanghai Institute of Geriatric Medicine,Shanghai 200030,China)
出处
《辽宁中医药大学学报》
2025年第8期88-92,共5页
Journal of Liaoning University of Traditional Chinese Medicine
基金
国家自然科学基金面上项目(81973899)
安徽中医药大学中医治未病临床科研项目(2024LC091)。
关键词
二丹红藤败酱汤加减
针刺
气滞血瘀型
盆腔炎性疾病后遗症
疗效
炎症指标
凝血指标
modified Erdan Hongteng Baijiang Decoction(二丹红藤败酱汤)
acupuncture
Qi stagnation and blood stasis syndrome
sequelae of pelvic inflammatory disease
therapeutic effect
inflammatory markers
coagulation index
作者简介
柯琴(1982-),女,安徽宁国人,副主任医师,硕士研究生导师,硕士,研究方向:中西医治疗生殖内分泌;通讯作者:刘特(1979-),男,上海人,教授,博士,研究方向:表观遗传学的研究。E-mail:liute1979@shutcm.edu.cn。
