摘要
目的:探讨牙周翻瓣术联合Bio-Guide生物膜治疗牙周牙髓联合病变的临床价值。方法:选取116例牙周牙髓联合病变患者,随机分为对照组(牙周翻瓣术治疗)和观察组(牙周翻瓣术联合Bio-Guide生物膜治疗),各58例。比较两组临床疗效以及治疗前后牙周指标、咬合与咀嚼功能、龈沟液中巨噬细胞炎症蛋白-1α(MIP-1α)、核因子κB受体活化因子配体(RANKL)水平。随访6个月,记录不良反应发生情况。结果:观察组总有效率高于对照组(P<0.05)。治疗后,两组牙周指标优于治疗前、最大咬合力及咀嚼效率较治疗前升高、龈沟液MIP-1α、RANKL水平较治疗前降低,且观察组上述指标优于对照组(均P<0.05)。观察组不良反应总发生率低于对照组(P<0.05)。结论:牙周翻瓣术联合Bio-Guide生物膜治疗牙周牙髓联合病变的临床疗效较好,可改善患者咬合及咀嚼功能,降低龈沟液MIP-1α、RANKL水平,且不良反应较少。
Objective:To investigate the clinical value of periodontal flap surgery combined with Bio-Guide biomembrane in the treatment of combined periodontal and pulpal lesions.Methods:One hundred and sixteen patients with combined periodontal and pulpal lesions were randomly assigned to a control group(periodontal flap surgery alone)and an observation group(periodontal flap surgery with Bio-Guide biomembrane),with 58 patients in each.The clinical efficacy was compared between the two groups.Periodontal indices,occlusal and masticatory functions,and levels of macrophage inflammatory protein-1α(MIP-1α)and receptor activator of nucleaRfactor-κB ligand(RANKL)in gingival creviculaRfluid were compared before and afteRtreatment.Follow-up was conducted for 6 months to record the incidence of adverse reactions.Results:The overall effectiveness rate in the observation group was higheRthan that in the control group(P<0.05).AfteRtreatment,periodontal indices in both groups were betteRthan those before treatment,the maximum bite force and masticatory efficiency were higheRthan those before treatment,and the levels of MIP-1αand RANKL in gingival creviculaRfluid were loweRthan those before treatment.Moreover,the observation group had betteRresults than the control group in the above indicators(all P<0.05).Additionally,the observation group had feweRadverse reactions(P<0.05).Conclusion:Periodontal flap surgery combined with Bio-Guide biomembrane has good clinical efficacy in the treatment of combined periodontal and pulpal lesions.It can improve occlusal and masticatory functions,reduce the levels of MIP-1αand RANKL in gingival creviculaRfluid,and has feweRadverse reactions.
作者
罗尔灵
林志兴
庄庆龙
LUO Erling;LIN Zhixing;ZHUANG Qinglong(Department of Stomatology,Quanzhou First Hospital Affiliated to Fujian Medical University,Quanzhou 362000,China;Department of Periodontology,Shenzhen Stomatology Hospital of Southern Medical University,Shenzhen 518000,China)
出处
《陕西医学杂志》
2025年第8期1076-1079,1084,共5页
Shaanxi Medical Journal
基金
福建省卫生健康委员会医学科学研究计划项目(2023DFG-1063)。
作者简介
第一作者:罗尔灵,硕士,主治医师,从事口腔临床医学相关研究,E-mail:xya3375@163.com。
