摘要
目的:分析血液灌流结合碘解磷定对急性重症有机磷农药中毒患者的治疗效果。方法:选取2020年1月—2024年8月铜仁市人民医院收治的90例急性重症有机磷农药中毒患者作为研究对象,按不同救治方案分为对照组40例,观察组50例。在常规救治时,对照组应用碘解磷定;观察组在碘解磷定治疗同时应用血液灌流;比较两组救治效果、胆碱酯酶(CHE)活性、天冬氨酸转氨酶(AST)水平等。结果:观察组临床症状缓解时间、阿托品使用剂量均低于对照组,治疗6 h、12 h、24 h、48 h时CHE活性高于对照组,差异有统计学意义(P<0.05)。治疗48 h观察组的血清肌酸激酶(CK)、心肌肌钙蛋白I(cTnI)、天冬氨酸转氨酶(AST)、谷丙转氨酶(ALT)水平均低于对照组,血清炎症表达低于对照组,差异有统计学意义(P<0.05)。两组并发症、死亡率发生率比较,差异无统计学意义(P>0.05)。结论:血液灌流结合碘解磷定可提高急性重症有机磷农药中毒患者CEH活性,减轻肝及心肌损伤。
Objective:To analyze the therapeutic effect of blood perfusion combined with iodothyroxine on patients with acute severe organophosphate pesticide poisoning.Method:Selecting 90 patients with acute severe organophosphate pesticide poisoning admitted to Tongren People's Hospital from January 2020 to August 2024.They were grouped according to different treatment plans.According to different treatment plans,they were divided into a control group of 40 cases and an observation group of 50 cases.During routine treatment,the control group was treated with iodipyrimidine.Hemoperfusion was applied in the observation group during the treatment with iodophosphatine.The treatment effects,cholinesterase(CHE)activity,aspartate aminotransferase(AST)levels,etc.of the two groups were compared.Result:The clinical symptom relief time and atropine dosage of the observation group were lower than those of the control group.The CHE activity was higher than that of the control group 6,12,24,and 48 h after treatment,and the difference was statistically significant(P<0.05).The levels of serum creatine kinase(CK),cardiac troponin I(cTnI),aspartate aminotransferase(AST),and alanine aminotransferase(ALT)of observation group were lower than those in the control group 48 h after treatment,and the expression of serum inflammation was lower than that in the control group,with statistically significant difference(P<0.05).There was no statistically significant difference in the incidence of complications and mortality between the two groups(P>0.05).Conclusion:The combination of hemoperfusion and iodothyroxine can improve the CEH activity in patients with acute severe organophosphate pesticide poisoning,alleviate liver and myocardial damage.
作者
李立
黄伟
许勇
LI Li;HUANG Wei;XU Yong(Tongren People's Hospital,Tongren 554300,China;不详)
出处
《中外医学研究》
2025年第19期53-56,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
碘解磷定
血液灌流
急性重症有机磷农药中毒
Iodothyroxine
Blood perfusion
Acute severe organophosphate pesticide poisoning
