摘要
目的 探讨黑质中不同方向纤维RGB分量转化各向异性分数(FA)分析在帕金森病(PD)中的应用价值。方法 PD患者35例,正常对照组37例。进行脑部弥散张量成像(DTI)扫描后,将序列导入3DSlicer 5.6.0软件中,利用Diffusion模块实现基于FA的伪彩映射,定位并分割出黑质,将黑质掩模作为追踪出发点。形成纤维追踪后,将其导入DTIANALYSIS 1.51软件中,将RGB分量转化为FA值进行分析并将分析结果可视化,同时对纤维长度、纤维密度及分段FA点云百分比进行比较。结果 与正常组相比,PD组黑质纤维长度较短(95.14 mm±19.85 mm vs 115.99 mm±21.39 mm,P<0.01),两者间差异存在统计学意义;在纤维密度上差异无统计学意义[(0.07±0.05)/mm3vs (0.1±0.12)/mm3,P>0.05];PD组0.9~1的FA区段点云占比较正常组低,但各FA区段点云比的主成分特征不明显。结论 基于RGB分量转化FA分析可对PD患者黑质神经纤维长度、密度和FA值进行量化和可视化分析,为PD神经通路研究提供依据。
Objective To explore the application value of fractional anisotropy(FA)analysis of RGB component transformation in different directions of fibers in substantia nigra in Parkinson’s disease(PD).Methods There were 35 cases of PD and 37 cases of normal control group.After being performed by brain diffusion tensor imaging(DTI)scanning,the sequence was imported into 3DSlicense 5.6.0,and the diffusion module was used to implement pseudo color mapping based on FA,locate and segment substantia nigra,and use the substantia nigra mask as the tracking starting point.After forming tracing,fibers were imported into DTIANALYSIS 1.51,converting the RGB components into FA values for analysis,and visualized the analysis result.At the same time,fiber length,fiber density,and segmented FA point cloud percentage were compared.Results Compared with the normal group,the length of substantia nigra fibers in the PD group was shorter[(95.14±19.85)mm vs(115.99±21.39)mm,P<0.01],and there was a statistical difference between the two groups.There was no statistical difference in fiber density[(0.07±0.05)/mm3 vs(0.10±0.12)/mm3,P>0.05]between control group and PD group.The percentage of FA segment point clouds in the PD group was lower than that in the normal group at 0.9-1,but the principal component characteristics of the point cloud ratios in each FA segment were not significant.Conclusion Based on the transformation of RGB components into FA analysis,the length,density,and FA values of substantia nigra nerve fibers in PD patients can be quantified and visualized,providing a basis for the study of PD neural pathways.
作者
刘羽卿
王小军
季达峰
孙海华
徐晓露
张新化
LIU Yu-qing;WANG Xiao-jun;JI Da-feng;SUN Hai-hua;XU Xiao-lu;ZHANG Xin-hua(Department of Human Anatomy,Medical School of Nantong University,Jiangsu Nantong 226001,China;Radiology Department,Affiliated Hospital 6 of Nantong University(Yancheng Third People’s Hospital),Jiangsu Yancheng 224000,China;Imaging Department of Nantong Fourth People’s Hospital,Jiangsu Nantong 226006,China;Department of Medical Informatics,Medical School of Natong University,Jiangsu Nantong 226001,China;Neurological Department,Affiliated Hospital 6 of Nantong University(Yancheng Third People’s Hospital),Jiangsu Yancheng 224000,China)
出处
《解剖学报》
2025年第4期459-465,共7页
Acta Anatomica Sinica
基金
南通大学临床医学专项科研基金项目(通大处科[2023]5号2023JZ017)
江苏医药职业学院临床学院专项科研发展基金(20229112)
盐城市医学科技发展计划项目(盐卫规划[2020]14号YK2020071)
盐城市基础研究计划指导性项目(盐科计[2023] 58号YCBK202216)。
关键词
帕金森病
黑质
纤维
弥散张量成像
可视化
人
Parkinson’s disease
Substantia nigra
Fiber
Diffusion tensor imaging
Visualization
Human
作者简介
刘羽卿(1989-),女(汉族),江苏省盐城市人,主管技师,在读硕士研究生;通讯作者:张新化,E-mail:zhangxinhua@ntu.edu.cn,Tel:(0513)85051718。
