摘要
帕金森病(PD)为中老年群体常见的神经系统退行性疾病,尽管PD的确切发病机制尚未彻底阐明,但近年来的研究不断揭示,线粒体功能障碍在PD的发病和进展过程中可能扮演着关键角色。线粒体作为细胞的能量工厂,是维持生命活动不可或缺的能量供应者。线粒体在氧化应激、自噬、生物发生、钙离子转运等过程中发生功能障碍,导致PD或加重疾病进展。文中旨在综述线粒体功能障碍在PD发病机制中的作用,及其在治疗方面的最新研究进展。
Parkinson's disease(PD)is a common neurodegenerative disorder in middle-aged and elderly pepole.Although the exact pathogenesis of PD has not been fully elucidated,recent research increasingly indicates that mitochondrial dysfunction may play a crucial role in its onset and progression.Mitochondria are indispensable for supplying the energy required for vital cellular activities.Functional impairments in mitochondria such as oxidative stress,autophagy,biogenesis,and calcium ion transport can trigger or exacerbate the progression of PD.The role of mitochondrial dysfunction in the pathogenesis of PD was reviewed and the latest advancements in therapeutic research were presented.
作者
任倩
方兴
田泽
REN Qian;FANG Xing;TIAN Ze(Graduate School of Guangxi University of Traditional Chinese Medicine,Nanning 530200,China;Ruikang Hospital,Guangxi University of Traditional Chinese Medicine,Nanning 53001l,China)
出处
《中国临床神经科学》
2025年第3期355-360,F0003,共7页
Chinese Journal of Clinical Neurosciences
基金
广西中医药大学附属瑞康医院院内课题(项目编号:S2020051)。
关键词
帕金森病
线粒体功能障碍
神经退行性病变
氧化应激
Parkinson's disease
mitochondrial dysfunction
neurodegenerative disease
oxidative stress
作者简介
任倩,硕士研究生,住院医师,主要从事神经病学的研究;通信作者:方兴,E-mail:zkzbfx@163.com。
