摘要
目的:分析血清氧化三甲胺在急性冠脉综合征诊断中的应用价值。方法:选择2023年4月—2024年3月于新乡医学院第一附属医院确诊急性冠脉综合征的100例患者作为病例组,将同期健康体检者(n=80)作为对照组。测定并比较两组血清氧化三甲胺水平,根据Gensini评分将病例组分为轻度组、中度组及重度组,比较三组血清氧化三甲胺水平;分析血清氧化三甲胺水平诊断急性冠脉综合征的效能以及急性冠脉综合征患者血清氧化三甲胺水平与冠状动脉狭窄程度的相关性。结果:病例组血清氧化三甲胺水平高于对照组(P<0.001)。不同冠状动脉狭窄程度患者血清氧化三甲胺水平比较,轻度组<中度组<重度组,差异有统计学意义(P<0.05)。血清氧化三甲胺诊断急性冠脉综合征的效能较高,AUC值为0.755。血清氧化三甲胺水平与冠状动脉狭窄程度呈正相关(P<0.001)。结论:血清氧化三甲胺在急性冠脉综合征诊断中的应用价值较高,可用于评估患者冠状动脉狭窄程度。
Objective:To analyze the application value of serum trimethylamine N-oxide in the diagnosis of acute coronary syndrome.Methods:A total of 100 patients with confirmed acute coronary syndrome in the First Affiliated Hospital of Xinxiang Medical University from April 2023 to March 2024 were selected as the case group,and the subjects who underwent physical examination during the same period(n=80)were selected as the control group.The serum trimethylamine N-oxide levels were measured and compared between the two groups.The case groups were divided into mild group,moderate group and severe group according to the Gensini score.The serum trimethylamine N-oxide levels of these three groups were compared.The diagnostic efficiency of serum trimethylamine N-oxide levels for acute coronary syndrome and the correlation between serum trimethylamine N-oxide levels and coronary artery stenosis degree in patients with acute coronary syndrome were analyzed.Results:The serum trimethylamine N-oxide levels in the case group were higher than those in the control group (P<0.001).The serum trimethylamine N-oxide levels in patients with different coronary artery stenosis degrees were compared and ranked as follows:mild group<moderate group<severe group,with a statistically significant difference(P<0.05).Serum trimethylamine N-oxide had high diagnostic efficiency for acute coronary syndromes,with an AUC of 0.755.The serum trimethylamine N-oxide level was positively correlated with the degree of coronary artery stenosis(P<0.001).Conclusion:Serum trimethylamine N-oxide has high application value in the diagnosis of acute coronary syndrome,and can be used to evaluate the degree of coronary artery stenosis in patients.
作者
王蔚蔚
赵国安
林飞
王瑞华
Wang Weiwei;Zhao Guoan;Lin Fei;Wang Ruihua(Department of Cardiology,The First Affiliated Hospital of Xinxiang Medical University,Xinxiang 453100,Henan Province,China;Department of Nuclear Medicine,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,Henan Province,China)
出处
《中国社区医师》
2025年第17期71-73,共3页
Chinese Community Doctors
关键词
急性冠脉综合征
冠状动脉造影
氧化三甲胺
诊断效能
Acute coronary syndrome
Coronary angiography
Trimethylamine N-oxide
Diagnostic efficiency
