摘要
中医药具有深厚的文化底蕴和悠久的历史传承,不仅是中华文明体系的重要构成部分,更构成了迄今为止保存最为完整的传统医学体系之一。长春花Catharanthus roseus作为具有重要药用价值的天然资源,其体内合成的萜类吲哚生物碱展现出一系列独特的药理活性特征。其中,以硫酸盐形式存在的长春碱和长春新碱作为国际公认的天然抗肿瘤药物前体,已在临床肿瘤治疗中得到广泛应用。现代药理学研究证实,该类活性成分在抗肿瘤、调节血糖、调控脂代谢等方面表现出显著的治疗潜力。通过系统梳理长春花生物碱的药效学特性,为深入解析其药用价值提供理论支撑,同时为其创新药物研发和临床转化应用指明研究方向。
Traditional Chinese medicine,with its deep cultural heritage and long history of inheritance,is not only an important component of Chinese civilisation system,but also one of the most completely preserved traditional medical systems so far.As a natural resource with important medicinal value,Changchunhua(Catharanthus roseus)exhibits a series of unique pharmacological activity profiles of terpenoid indole alkaloids synthesized in its body.Among these,vinblastine and vincristine,existing in the form of sulphate,have been widely used in clinical oncology treatment as internationally recognised natural antitumor drug precursors.Modern pharmacological studies have confirmed that this class of active ingredients has shown significant therapeutic potential in antitumor,bloodglucose regulation,and lipid metabolism regulation.By systematically combing the pharmacodynamic properties of alkaloids in Catharanthus roseus,this paper provides a theoretical support for in-depth analysis of their medicinal value,andpoints out research directions for innovative drug research and development and clinical translational application.
作者
张思祺
徐思怡
林小伟
史若愚
于海洋
ZHANG Siqi;XU Siyi;LIN Xiaowei;SHI Ruoyu;YU Haiyang(College of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;State Key Laboratory of Natural and Biomimetic Drugs,Peking University,Beijing 100191,China;First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China;School of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Tianjin Key Laboratory of Modern Chinese Medicine Theory of Innovation and Application,Tianjin 301617,China)
出处
《中草药》
北大核心
2025年第12期4490-4498,共9页
Chinese Traditional and Herbal Drugs
基金
天津市自然科学基金资助项目(23JCJQJC00040)
天然药物及仿生药物全国重点实验室开放基金资助项目(K202417)。
关键词
长春花生物碱
长春碱
长春新碱
抗肿瘤
血管生成
免疫
降血糖
调血脂
alkaloids in Catharanthus roseus
vinblastine
vincristine
antitumor
angiogenesis
immunity
hypoglycemic
blood lipid regulation
作者简介
张思祺,硕士研究生,研究方向为中药抗肿瘤药理。E-mail:zhangsq202109@163.com;通信作者:史若愚,副主任医师,从事中西医结合危重症研究。E-mail:mydreamfish@126.com;通信作者:于海洋,教授,博士生导师,从事中药抗肿瘤药理研究。E-mail:hyyu@tjutcm.edu.cn。
