摘要
肿瘤微环境是肿瘤发生发展过程中至关重要的核心因素,其中,缺氧微环境在肿瘤组织中广泛存在,是加速肿瘤恶化进程的关键内源性因素。“瘀毒”理论作为新兴的肿瘤研究视角,因其动态演变机制与缺氧微环境的形成高度相似,被视为肿瘤进展中的独特中医“土壤”。科学结合中医理论与肿瘤的生物学特性,探索精准辨证施治之道,是实现肿瘤整体防控的关键所在。该文聚焦肿瘤缺氧微环境,阐释其形成机制与演变过程,细致解析“瘀毒”理论与缺氧微环境的内在关联,探讨瘀血、毒邪与缺氧环境之间的交互关系,并提出基于“瘀毒”理论的中药调控缺氧微环境的微观防治策略,以期为缺氧微环境的精准调控提供中医特色的理论依据与治疗思路。
TThe tumor microenvironment is a crucial factor in tumor occurrence and progression.The hypoxic microenvironment is widely present in tumor tissue and is a key endogenous factor accelerating tumor deterioration.The"blood stasis toxin"theory,as an emerging perspective in tumor research,is regarded as the unique"soil"in tumor progression from the perspective of traditional Chinese medicine(TCM)due to its dynamic evolution mechanism,which closely resembles the formation of the hypoxic microenvironment.Scientifically integrating TCM theories with the biological characteristics of tumors and exploring precise syndrome differentiation and treatment strategies are key to achieving comprehensive tumor prevention and control.This article focused on the hypoxic microenvironment of the tumor,elucidating its formation mechanisms and evolutionary processes and carefully analyzing the internal relationship between the"blood stasis toxin"theory and the hypoxic microenvironment.Additionally,it explored the interaction among blood stasis,toxic pathogens,and hypoxic environment and proposed micro-level prevention and treatment strategies targeting the hypoxic microenvironment based on the"blood stasis toxin"theory,aiming to provide TCM-based theoretical support and therapeutic approaches for precise regulation of the hypoxic microenvironment.
作者
范微
吕媛琳
倪晓晨
张开源
王楚航
郭嘉宁
张光霁
黄建波
姜涛
FAN Wei;LYU Yuan-lin;NI Xiao-chen;ZHANG Kai-yuan;WANG Chu-hang;CUO Jia-ning;ZHANG Guang-ji;HUANG Jian-bo;JIANG Tao(School of Basic Medical Sciences,Zhejiang Chinese Medical University,Hangzhou 310053,China;Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome,Zhejiang Chinese Medical University,Hangzhou 310053,China;Traditional Chinese Medicine"Preventing Disease"Wisdom Health Project Research Center of Zhejiang,Hangzhou 310053,China;Zhejiang Culture Research Institute of Chinese Medicine,Zhejiang Chinese Medical University and Key Cultivating Base of Zhejiang Philosophy and Social Sciences,Hangzhou 310053,China)
出处
《中国中药杂志》
北大核心
2025年第12期3483-3488,共6页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(82204950)
浙江省自然科学基金项目(Q23H270031)
浙江省中医药科技计划青年人才支持计划项目(2025ZR102)
国家自然科学基金区域创新发展联合基金重点项目(U23A20499)。
关键词
缺氧微环境
瘀毒
血管生成
微观辨证
肿瘤
hypoxic microenvironment
blood stasis toxin
angiogenesis
micro syndrome differentiation
tumor
作者简介
通信作者:姜涛,副教授,硕士生导师,主要从事中医药肿瘤防治机制及临床研究,E-mail:jttcm@zcmu.edu.cn;范微,硕士研究生,E-mail:fanwei12170102@163.com。
