摘要
目的应用扩散峰度成像(diffusion kurtosis imaging,DKI)技术探讨注意力缺陷多动障碍(attention deficit hyperactivity disorder,ADHD)患儿脑白质纤维束的微结构特征。材料与方法本研究前瞻性纳入29名经我院首次诊断为ADHD的儿童[年龄(8.31±1.25)岁]和27名健康对照(healthy control,HC)儿童[年龄(8.85±1.21)岁]。所有受试者均接受头颅磁共振平扫以及DKI扫描并对ADHD组儿童进行斯诺佩评估量表第四版(the Swanson,Nolan,and PelhamⅣScale,SNAP-Ⅳ)的评估。采用基于束的空间统计学方法(tract-based spatial statistics,TBSS)分析研究ADHD儿童的白质纤维束损伤情况。经过后处理得到扩散张量和扩散峰度参数,并分析比较了这些参数在两组之间的差异,将组间有显著差异参数值与ADHD儿童的SNAP-Ⅳ量表结果进行相关分析。结果与HC组相比,ADHD儿童的胼胝体的压部、膝部和体部,双侧丘脑后辐射(包括视辐射),右扣带束、右下纵束和下额枕束、右后放射冠、右外囊及右内囊后部,左前及左上放射冠、左内囊前后肢、穹窿脑白质纤维束各向异性分数(fractional anisotropy,FA)参数值降低(P<0.05),其他参数值差异均无统计学意义(P<0.05);所有分析结果均经过多重比较校正。相关性分析发现,ADHD组儿童的胼胝体压部(r=-0.390,P=0.018)、右侧下纵束和下额枕束(r=-0.374,P=0.023)的平均FA值与ADHD儿童的SNAP-Ⅳ量表评分中的多动冲动得分具有负相关性。结论DKI技术能够揭示ADHD患儿的脑微结构异常,胼胝体压部、右侧下纵束和下额枕束的FA值降低与ADHD儿童的多动冲动相关。DKI技术可能为探索白质纤维束异常提供了新的方向。
Objective:To explore the microstructural characteristics of white matter fiber tracts in children with attention deficit hyperactivity disorder(ADHD)using diffusion kurtosis imaging(DKI)technology.Materials and Methods:This study prospectively analysed 29 children with ADHD[mean age:(8.31±1.25)years],newly diagnosed at our institution,and 27 healthy control(HC)children[mean age:(8.85±1.21)years].All participants underwent conventional magnetic resonance imaging(MRI)and DKI scans.Children in the ADHD group were additionally assessed using the Swanson,Nolan,and PelhamⅣ(SNAP-Ⅳ)scale.Tract-based spatial statistics(TBSS)were employed to analyze white matter tract alterations in ADHD.Post-processing yielded diffusion tensor and diffusion kurtosis parameters,which were compared between groups.Significant parameters were correlated with SNAP-Ⅳscores.Results:Compared to HC,ADHD children exhibited significantly reduced fractional anisotropy(FA)values(P<0.05,corrected for multiple comparisons)in the splenium,genu,and body of the corpus callosum;bilateral posterior thalamic radiations(including optic radiations);right cingulum,right inferior longitudinal fasciculus(ILF),right inferior fronto-occipital fasciculus(IFOF),right posterior corona radiata,right external capsule,and right posterior limb of the internal capsule;left anterior/superior corona radiata,left anterior/posterior limbs of the internal capsule;and fornix.No significant differences were observed in other parameters(P>0.05).Correlation analysis revealed negative associations between FA values in the splenium of the corpus callosum(r=−0.390,P=0.018)and the right ILF/IFOF(r=−0.374,P=0.023)with hyperactivity-impulsivity scores on the SNAP-Ⅳ.Conclusions:DKI reveals microstructural abnormalities in the brains of children with ADHD.Reduced FA in the splenium of the corpus callosum and right ILF and IFOF correlates with hyperactivity-impulsivity symptoms.DKI may provide novel insights into white matter abnormalities in ADHD.
作者
刘世鹏
程美英
鲁钰
李思柯
王长浩
沈艳勇
周梁
冯刘娟
赵鑫
LIU Shipeng;CHENG Meiying;LU Yu;LI Sike;WANG Changhao;SHEN Yanyong;ZHOU Liang;FENG Liujuan;ZHAO Xin(Department of Medical Imaging,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Henan International Joint Laboratory of Neuromedical Imaging,Zhengzhou 450052,China;Henan Provincial Key Laboratory of Pediatric Neuroimaging Medicine,Zhengzhou 450052,China)
出处
《磁共振成像》
北大核心
2025年第5期62-67,87,共7页
Chinese Journal of Magnetic Resonance Imaging
基金
国家自然科学基金项目(编号:82472046)
河南省科技攻关计划项目(编号:232102311091)。
关键词
儿童
注意力缺陷多动障碍
白质
扩散峰度成像
基于束的空间统计学方法
磁共振成像
children
attention deficit hyperactivity disorder
white matter
diffusion kurtosis imaging
tract-based spatial statistics
magnetic resonance imaging
作者简介
通信作者:赵鑫,E-mail:zdsfyzx@zzu.edu.cn。
