摘要
目的采用静息态功能连接(restingstatefunctionalconnectivity,rs-FC)和动态功能连接(dynamicfunctional connectivity,dFC)方法观察广泛性焦虑症(generalized anxiety disorder,GAD)异常改变特征。材料与方法前瞻性纳入GAD患者35例和健康对照(healthy control,HC)35例,对两组被试分别采集功能磁共振成像(functional magnetic resonance imaging,fMRI)数据,以杏仁核为种子点,观察两组被试双侧杏仁核的rs-FC和dFC异常改变特征,并进一步将差异脑区与临床症状进行相关性分析。结果在rs-FC方面,GAD组左侧杏仁核与左侧眶部额下回、左侧中央后回、左侧枕上回、左侧颞中回颞极(t=-2.236、-2.220、-2.222、-2.230,P<0.005)的rs-FC较HC组减低,右侧杏仁核与左侧额中回、左侧辅助运动区、左侧中央后回(t=-2.297、-2.296、-2.299,P<0.005)的rs-FC较HC组减低;在dFC方面,GAD组左侧杏仁核与右侧颞中回、左侧楔前叶(t=-2.236、-2.220,P<0.005)的dFC较HC组减低,右侧杏仁核与右侧眶部额中回、右侧岛叶dFC较HC组减低(t=-2.297、-2.296,P<0.005),且GAD组右侧杏仁核与左侧额中回的rs-FC值和17项汉密尔顿抑郁量表(Hamilton Depression Scale 17,HAMD-17)评分呈负相关(r=-0.425,P=0.013)。结论GAD患者杏仁核与局部脑区存在静态与动态功能连接异常,主要包括奖赏网络、默认网络、额顶网络和视觉网络,本研究为了解GAD脑功能活动异常神经病理机制提供一定参考价值。
Objective:To observe the abnormal characteristics of generalized anxiety disorder(GAD)through resting-state functional connectivity(rs-FC)and dynamic functional connectivity(dFC)methods.Materials and Methods:A total of 35 patients with GAD and 35 healthy controls(HC)were prospectively recruited.Functional magnetic resonance imaging(fMRI)data were collected for both groups,using the amygdala as a seed point to observe the abnormalities in rs-FC and dFC of the bilateral amygdala.Additionally,a correlation analysis was conducted between the differential brain regions and clinical symptoms.Results:In terms of rs-FC,the GAD group exhibited reduced rs-FC between the left amygdala and the left orbitofrontal cortex,left postcentral gyrus,left superior occipital gyrus,and left middle temporal(t=−2.236,−2.220,−2.222,−2.230,P<0.005)gyrus compared to the HC group.The right amygdala also demonstrated decreased rs-FC with the left middle frontal gyrus,left supplementary motor area,and left postcentral gyrus(t=−2.236,−2.220,−2.222,−2.230,P<0.005)in the GAD group.Regarding dFC,the GAD group showed reduced dFC between the left amygdala and the right middle temporal gyrus(t=−2.236,−2.220,P<0.005),as well as the left precuneus compared to HCs.The right amygdala's dFC with the right orbitofrontal cortex and right insula(t=−2.297,−2.296,P<0.005)was also lower in the GAD group.Furthermore,there was a negative correlation between the rs-FC value of the right amygdala and the left middle frontal gyrus and the Hamilton Depression Scale 17(HAMD-17)score in the GAD group(r=−0.425,P=0.013).Conclusions:Patients with GAD exhibit abnormal static and dynamic functional connectivity of the amygdala with local brain regions,primarily involving the reward network,default mode network,frontoparietal network,and visual network.This study provides valuable insights into the neurobiological mechanisms underlying the abnormal brain functional activity in GAD.
作者
张磊
王小玲
孙继飞
曹久冬
洪洋
罗萍
孙黎
吕学玉
刘军
赖菁玲
方继良
郎学森
ZHANG Lei;WANG Xiaoling;SUN Jifei;CAO Jiudong;HONG Yang;LUO Ping;SUN Li;LÜ Xueyu;LIU Jun;LAI Jingling;FANG Jiliang;LANG Xuesen(Department of Radiology,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Department of Neurology,Shunyi Hospital,Beijing Traditional Chinese Medicine Hospital,Beijing 101300,China)
出处
《磁共振成像》
北大核心
2025年第5期49-53,61,共6页
Chinese Journal of Magnetic Resonance Imaging
基金
中国中医科学院科技创新工程项目(编号:CI2021A03304)。
关键词
广泛性焦虑症
杏仁核
静息态功能连接
动态功能连接
磁共振成像
generalized anxiety disorder
amygdala
resting-state functional connectivity
dynamic functional connectivity
magnetic resonance imaging
作者简介
通信作者:郎学森,E-mail:wolangba@163.com。
