摘要
目的探讨口服甘油对梅尼埃病(Ménière disease,MD)患者纯音听阈测试(pure tone audiometry,PTA)、畸变产物耳声发射(distortion products otoacoustic emission,DPOAE)及耳蜗电图(electrocochleography,ECochG)结果的影响。方法50例(60耳)MD患者口服甘油前及口服甘油后1、2、3 h行纯音听阈测试,口服甘油前、口服甘油后2 h行DPOAE及ECochG测试。分析口服甘油对上述测试结果的影响及结果之间的相关性。结果①PTA甘油试验阳性率为55.00%(33/60),口服甘油后1~3 h阳性率逐渐升高(P<0.05),观察的3 h内,阳性耳的听阈下降于口服甘油3 h后达到峰值,听阈均值下降最快时段为口服甘油后1~2 h,听阈均值变化最大的三个频率为0.5、1、2 kHz;②DPOAE甘油试验阳性率为56.67%(34/60),阳性耳幅值变化相对较大的f 2频率范围为0.75~2 kHz;③ECochG甘油试验阳性率为13.64%(6/44),口服甘油前后-SP/AP>0.4的阳性率无统计学差异(P>0.05)。结论口服甘油可改变MD患者耳蜗功能,不同程度地影响PTA、DPOAE和ECochG测试结果。
Objective To investigate the effects of glycerol ingestion on pure tone audiometry(PTA),distortion products otoacoustic emission(DPOAE),and electrocochleography(ECochG)in patients with Ménière disease(MD).Methods Glycerol test was conducted in 50 patients with MD.PTA was performed in four series:before glycerol intake,1,2 and 3 hours after intake.DPOAE and ECochG were performed before glycerol intake and 2 hours after intake.All results were analyzed to assess the effect of glycerol on cochlear function of patients with MD.Results①55%of MD patients tested positive in PTA glycerol test,and the positive rate increased gradually after 1-3 hours of glycerin ingestion(P<0.05).For the 33 positive ears,the pure tone threshold decreased the most between 1-2 hours and reached the lowest thresholds at 3 hours.Thresholds at 0.5 kHz,1 kHz,2 kHz dropped the most.②The positive rate of DPOAE glycerol test was 56.67%,with 34 positive ears showing a significant increase in amplitude between 0.75-2 kHz of f 2.③The positive rate of ECochG glycerin test was 13.64%.The decrease of-SP/AP ratio was not statistically significant before and after ingestion of glycerin(P>0.05).Conclusion Ingestion of glycerin could alter to varying degrees of the results of PTA,DPOAE and ECochG,and influence the cochlear function to some extent.
作者
潘慧
王琳琳
罗成
龚萌
吴梦君
舒毅
谢文
肖红俊
刘波
PAN Hui;WANG Linlin;LUO Cheng;GONG Meng;WU Mengjun;SHU Yi;XIE Wen;XIAO Hongjun;LIU Bo(Department of Otorhinolaryngology—Head Neck Surgery and ENT Institute,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Hubei Clinical Medical Research Center of Deafness and Vertigo,Wuhan 430022,China)
出处
《听力学及言语疾病杂志》
北大核心
2025年第4期372-376,共5页
Journal of Audiology and Speech Pathology
基金
国家重点研发计划(2023YFC2508400、2023YFC2508000、2023YFC2508001)
国家自然科学基金项目(81670930)
湖北省自然科学基金(2021CFB547)。
关键词
梅尼埃病
甘油试验
纯音听阈测试
畸变产物耳声发射
耳蜗电图
Ménière disease
Glycerol test
Pure tone audiometry
Distortion products otoacoustic emission
Electrocochleography
作者简介
通信作者:刘波,Email:liuboent@hust.edu.cn。
