摘要
宫腔粘连(intrauterine adhesions,IUA)是指因宫腔机械性损伤和(或)感染引起的子宫内膜修复障碍,表现为宫腔不同程度的腔体闭塞,引发月经异常、反复流产和不孕等生殖内分泌功能异常。在临床中发现无任何宫腔操作史也会形成IUA,因此认为IUA的形成还与其他因素有关。随着基因组测序技术的出现,研究发现生殖道菌群在IUA的发展中起主要作用。当生殖道菌群失调时(如保护性乳杆菌数量的减少等)会导致生殖道免疫应答下降,从而增加了被致病菌感染的风险,引起炎症反应,导致生殖道黏膜受损,进而增加了IUA的风险。本文就生殖道菌群与IUA发生的相关性研究进展作一综述。
Intrauterine adhesions(IUA)is a disorder of endometrial repair caused by mechanical injury and/or infection of uterine cavity,which manifests itself as varying degrees of luminal occlusion of uterine cavity,triggering abnormalities of menstruation,recurrent miscarriage,infertility and other abnormalities of reproductive endocrine functions.In clinical prac-tice,IUA has been found to develop without any history of uterine manipulation,so it is believed that the formation of IUA is also related to other factors.With the advent of genome sequencing technology,it has been found that reproductive tract flora plays a role in the development of IUA.When the reproductive tract flora is imbalanced,the decrease in the amount of protective Lactobacillus leads to a decrease in the immune response in the reproductive tract,which increases the risk of in-fection by pathogenic bacteria,causing an inflammatory response leading to damage to the mucosa of reproductive tract,which in turn increases the risk of IUA.In this paper,we review the progress in research on the correlation between repro-ductive tract flora and the occurrence of IUA.
作者
许莉欣
廉红梅
XU Lixin;LIAN Hongmei(School of Medicine,Wuhan University of Science and Technology,Wuhan,Hubei 430070,China;不详)
出处
《中国微生态学杂志》
北大核心
2025年第5期612-616,共5页
Chinese Journal of Microecology
基金
湖北省卫生健康委员会科研立项面上项目(WJ2021M187)。
关键词
宫腔粘连
生殖道菌群
菌群失调
基因测序技术
Intrauterine adhesion
Reproductive tract flora
Dysbacteriosis
Gene sequencing technology
作者简介
许莉欣(1992-),女,硕士,从事妇科内分泌研究,E-mail:1379892917@qq.com;通信作者:廉红梅,E-mail:lianlianan@qq.com。
