摘要
目的:探讨计算机断层扫描(CT)联合血清三叶肽因子-1(TFF-1)、肿瘤特异性生长因子(TSGF)对肝细胞癌(HCC)的临床诊断价值。方法:选取2021年10月至2023年10月收治的经病理检测确诊为HCC患者75例(肝癌组),良性病变患者42例(对照组)。所有患者入院时采用64排螺旋CT进行CT影像学检测。用酶联免疫吸附法检测血清TFF-1、TSGF水平。Kappa检验CT影像学与病理学检测的一致性。绘制ROC曲线分析CT影像学联合血清TFF-1、TSGF检测对HCC的临床诊断价值。结果:Kappa检验显示,CT影像学与病理学检测的一致性一般(Kappa值=0.531)。肝癌组和对照组患者CT影像学图像肿块形态、侵犯周围血管、结构清晰、平扫密度、动脉期强化、门静脉期密度、延迟期强化比较差异有统计学意义(P<0.05)。与对照组比较,肝癌组患者血清中TFF-1、TSGF水平均显著升高(P<0.05)。与CT、血清TFF-1、TSGF单独诊断相比,联合诊断HCC发生的AUC显著升高(P<0.001)。结论:HCC患者血清中TFF-1、TSGF水平高表达,CT、血清TFF-1、TSGF对HCC有一定的诊断价值,三者联合检测能够提高对HCC的诊断效能。
Objective:To explore the clinical diagnostic value of computed tomography(CT)imaging combined with serum trefoil factor-1(TFF-1)and tumor specific growth factor(TSGF)for hepatocellular carcinoma.Methods:A total of 117 suspected hepatocellular carcinoma patients in our hospital from October 2021 to October 2023 were gathered.Among them,75 patients diagnosed with hepatocellular carcinoma through pathological examination were included as the liver cancer group,and 42 patients with benign lesions were included as the control group.All patients were examined for CT imaging using a 64 slice spiral CT scanner upon admission.ELISA method was applied to detect serum TFF-1 and TSGF levels.Kappa was applied to verify the consistency between CT imaging and pathological detection.ROC curve was plotted to analyze the clinical diagnostic value of CT imaging combined with serum TFF-1 and TSGF for hepatocellular carcinoma.Results:The Kappa test showed that the consistency between CT imaging and pathological detection was average(Kappa value=0.531).There were significant differences in CT images of tumor morphology,invasion of peripheral blood vessels,clear structure,plain scan density,arterial stage enhancement,portal vein stage enhancement and delayed stage enhancement between HCC group and control group(P<0.05).Compared with the control group,the levels of TFF-1 and TSGF in the serum of liver cancer patients were obviously higher(P<0.05).Compared with the separate diagnosis of CT imaging,serum TFF-1,and TSGF,the AUC of combined diagnosis of hepatocellular carcinoma was obviously higher(Z CT imaging~CT imaging+TFF-1+TSGF=4.617,P<0.001;Z TFF-1~CT imaging+TFF-1+TSGF=3.224,P=0.001;Z TSGF~CT imaging+T FF-1+TSGF=3.435,P=0.001).Conclusion:TFF-1 and TSGF levels are highly expressed in the serum of patients with hepatocellular carcinoma.CT imaging,serum TFF-1,and TSGF have certain diagnostic value for the occurrence of hepatocellular carcinoma.The combined detection of the three can improve the diagnostic efficiency for hepatocellular carcinoma.
作者
李秋实
徐珂
杨洁
LI Qu-shi;XU Ke;YANG Jie(Medical Imaging Department,The First Hospital of Henan University(Kaifeng Henan,475000),China)
出处
《中西医结合肝病杂志》
2025年第6期733-736,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
基金
开封市科技发展计划项目(No.2203032)。
作者简介
通讯作者:杨洁,E-mail:xip6egy@163.com。
