摘要
目的探索青少年单、双相抑郁障碍患者炎症细胞因子水平的差异。方法纳入年龄15~24岁的重性抑郁障碍患者32例(单相组)、双相障碍抑郁发作患者53例(双相组)、健康对照25名(对照组)。采用17项汉密尔顿抑郁量表(17-item Hamilton depression scale,HAMD-17)、汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)、32项轻躁狂症状清单(32-item hypomania checklist,HCL-32)评定患者的临床症状;采用酶联免疫吸附测定法检测所有受试者外周血的血清炎症细胞因子水平。结果与单相组相比,双相组发病年龄更小、总病程更长、本次病程更短、HAMD评分更低、HCL-32评分更高,差异有统计学意义(P<0.05)。三组间白介素(interleukin,IL)-1β、IL-6、干扰素γ(interferon-γ,INF-γ)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、肿瘤坏死因子受体2(tumor necrosis factor receptor 2,TNFR2)、IL-4、IL-10、IL-13水平比较差异有统计学意义(P<0.05)。两两比较显示,和对照组相比,单相组和双相组的促炎细胞因子IL-1β、IL-6、TNF-α水平升高(均P<0.05),而抗炎细胞因子IL-4、IL-10、IL-13水平降低(均P<0.05);双相组INF-γ、TNFR2水平高于对照组(P<0.05);与单相组相比,双相组的INF-γ[43.25(29.27,53.63)pg/mL vs.62.76(39.27,89.16)pg/mL]、IL-13[16.92(14.74,24.02)pg/mL vs.22.29(17.35,36.52)pg/mL]升高。多因素logistic回归分析显示,IL-13(OR=1.078,95%CI:1.011~1.150,P=0.022)与双相抑郁障碍独立相关联。结论青少年单、双相抑郁障碍患者存在炎症细胞因子的改变,双相障碍抑郁发作患者的IL-13、INF-γ水平高于重性抑郁障碍患者,较高水平的IL-13与双相障碍抑郁发作具有相关性。
Objective To explore the differences in inflammatory cytokine levels between adolescent patients with unipolar and bipolar depressive disorders.Methods A total of 32 patients aged 15-24 years with major depressive disorder(unipolar group),53 patients with bipolar depressive episodes(bipolar group),and 25 healthy controls(control group)were enrolled.The 17-item Hamilton depression scale(HAMD-17),Hamilton anxiety scale(HAMA),and 32-item hypomania checklist(HCL-32)were used to assess the clinical symptoms of the patients.The levels of inflammatory cytokines in all samples were measured using the enzyme-linked immunosorbent assay(ELISA)method.Results Compared with the unipolar group,the bipolar group had an earlier age of onset,a longer total disease duration,a shorter current episode duration,lower HAMD scores,and higher HCL-32 scores,with significant differences(P<0.05).There were significant differences in the levels of interleukin-1β(IL-1β),IL-6,interferon-γ(INF-γ),tumor necrosis factor-α(TNF-α),tumor necrosis factor receptor 2(TNFR2),IL-4,IL-10,and IL-13 among the three groups of subjects(P<0.05).Pairwise comparison showed that compared with the control group,both unipolar and bipolar groups exhibited the significant elevations in pro-inflammatory cytokines IL-1β,IL-6,and TNF-α(all P<0.05)and remarkable reductions in the anti-inflammatory cytokines IL-4,IL-10,and IL-13(all P<0.05).The levels of INF-γand TNFR2 were significantly higher in the bipolar group than in the control group(P<0.05).Compared with the unipolar group,the levels of INF-γ[43.25(29.27,53.63)pg/mL vs.62.76(39.27,89.16)pg/mL]and IL-13[16.92(14.74,24.02)pg/mL vs.22.29(17.35,36.52)pg/mL]were significantly increased in the bipolar group.Multivariate logistic regression analysis showed that IL-13(OR=1.078,95%CI:1.011-1.150,P=0.022)was independently associated with bipolar depressive disorder.Conclusion Adolescents with unipolar and bipolar depressive disorders exhibit changes in inflammatory cytokines,and the IL-13 and INF-γare higher in bipolar depressive episodes than in major depressive disorder.Higher levels of IL-13 are associated with bipolar depressive disorder.
作者
贾海玲
杨永涛
崔利军
JIA Hailing;YANG Yongtao;CUI Lijun(Hebei Mental Health Center,The Sixth Clinical Medical College of Hebei Universitiy,Baoding 071000,China)
出处
《中国神经精神疾病杂志》
北大核心
2025年第5期286-292,共7页
Chinese Journal of Nervous and Mental Diseases
基金
河北省财政厅、河北省卫生健康委政府资助临床医学优秀人才项目(编号:361014)。
关键词
青少年
双相障碍
重性抑郁障碍
炎症
细胞因子
促炎细胞因子
抗炎细胞因子
IL-13
Adolescents
Bipolar disorder
Major depressive disorder
Inflammation
Cytokines
Proinflamma-tory cytokines
Antiinflammatory cytokines
IL-13
作者简介
通信作者:崔利军(E-mail:cuilijun2013@163.com).Tel:0312-7557012.
