摘要
目的探究急性脑梗死(ACI)患者血清甲硫氨酸亚砜还原酶B3(MSRB3)、白细胞介素-8(IL-8)水平对脑梗死后认知功能障碍的预测价值。方法本研究为回顾性病例对照研究, 选取2021年12月至2023年12月长安医院神经内科收治的137例ACI患者, 男92例, 女45例, 年龄(62.1±6.7)岁, 年龄范围为55~71岁。依据蒙特利尔认知评估量表(MoCA)<22分为认知功能障碍, ≥22分为认知功能正常将患者分为卒中后认知功能障碍(PSCI)组(n=47)与卒中后无认知功能障碍(PSNCI)组(n=90)。本研究另选取70例于长安医院体检科进行体检的健康人群作为健康对照组。收集所有纳入者临床资料, 检测所有纳入者血清中IL-8和MSRB3表达水平。采用logistic回归分析影响ACI患者发生PSCI的独立危险因素, 采用受试者操作特征曲线分析MSRB3、IL-8对ACI患者PSCI发生的预测价值。结果 PSNCI组患者红细胞计数高于PSCI组, 梗死灶数量与PSCI组比较, 差异均有统计学意义(P<0.05)。PSCI组、PSNCI组患者血清IL-8水平[(8.63±1.67)μg/L、(6.79±1.58)μg/L]均高于健康对照组[(4.22±0.15)μg/L], MSRB3[(0.63±0.16)、(0.81±0.13)]均低于健康对照组(1.01±0.03), 差异均有统计学意义(P<0.05)。logistic回归分析结果显示, MSRB3低水平(OR=0.856, 95%CI:0.756~0.968)、IL-8高水平(OR=1.214, 95%CI:1.007~1.464)为ACI患者发生PSCI的独立危险因素(P<0.05)。MSRB3、IL-8联合预测PSCI的曲线下面积高于各指标的单独预测价值(Z=3.066, P=0.002;Z=3.052, P=0.002)。结论 MSRB3低水平、IL-8高水平为ACI患者发生PSCI的独立危险因素, MSRB3、IL-8联合预测PSCI的诊断效能高于各指标单独预测。
Objective To investigate the predictive value of serum methionine sulfoxide reductase B3(MSRB3)and interleukin 8(IL-8)levels in patients with acute cerebral infarction(ACI)on cognitive dysfunction after cerebral infarction.Methods This study was a retrospective case-control study,a total of 137 patients with ACI admitted to the department of Neurology of Chang'an Hospital from December 2021 to December 2023,including 92 males and 45 females,aged(62.1±6.7)years old,ranging from 55 to 71 years old.The patients were divided into post-stroke cognitive impairment(PSCI)group(n=47)and post-stroke no cognitive impairment(PSNCI)group(n=90)based on the Montreal cognitive assessment(MoCA)<22 points for cognitive dysfunction and≥22 points for normal cognitive function.Another 70 healthy individuals who received a physical examination at the department of Medical Examination in Chang'an Hospital were selected as the healthy control group in this study.Clinical data were collected from all the participants,detect the expression levels of IL-8 and MSRB3 in the serum of all the participants.Logistic regression was used to analyze the independent risk factors affecting the occurrence of PSCI in patients with ACI,and the predictive value of MSRB3 and IL-8 on the occurrence of PSCI in patients with ACI was analyzed by receiver operator characteristic curve.Results The erythrocyte counts of patients in the PSNCI group was higher than that in the PSCI group,and the number of infarct foci compared with that in the PSCI group,the differences were statistically significant(P<0.05).The serum IL-8 levels of patients in the PSCI group and the PSNCI group[(8.63±1.67)μg/L,(6.79±1.58)μg/L] were higher than that in the healthy control group[(4.22±0.15)μg/L],and MSRB3[(0.63±0.16),(0.81±0.13)]were lower than that in the healthy control group(1.01±0.03),and the differences were statistically significant(P<0.05).Logistic regression analysis showed that MSRB3 at low level(OR=0.856,95%CI:0.756 to 0.968),IL-8 at high level(OR=1.214,95%CI:1.007 to 1.464)were independent risk factors for the occurrence of PSCI in patients with ACI(P<0.05).The area under the curve of the combination of MSRB3 and IL-8 in the prediction of PSCI was higher than the predictive value of each index individually(Z=3.066,P=0.002;Z=3.052,P=0.002).ConclusionsMSRB3 at low level and IL-8 at high level were independent risk factors for the occurrence of PSCI in patients with ACI,and combined prediction MSRB3 and IL-8 in the prediction of PSCI was higher than the predictive value of each index individually.
作者
王翠玉
雍晓莉
安升
魏亮
陈小剑
汪恒胜
Wang Cuiyu;Yong Xiaoli;An Sheng;Wei Liang;Chen Xiaojian;Wang Hengsheng(Department of Neurology,Chang'an Hospital,Xi'an 710016,China;Department of Medical Examination,Chang'an Hospital,Xi'an 710016,China)
出处
《中国临床实用医学》
2025年第2期109-114,共6页
China Clinical Practical Medicine
基金
陕西省重点研发计划项目(2024SF-YBXM-084)。
作者简介
通信作者:雍晓莉,Email:893754089@qq.com。
