摘要
目的分析老年稳定期慢性阻塞性肺疾病(COPD)患者采用桉柠蒎肠溶软胶囊联合噻托溴铵-奥达特罗联合治疗方式对呼吸力学和预后的影响。方法选取2022年3月—2023年3月在本院就诊且符合纳入标准的老年稳定期COPD患者70例为研究对象,按照随机数字表法将其分为对照组和观察组,每组35例。对照组采取噻托溴铵-奥达特罗治疗,观察组患者采取桉柠蒎肠溶软胶囊联合噻托溴铵-奥达特罗治疗。分析两组患者治疗效果,评估指标为治疗前后患者呼吸困难指数(mMRC)评分、圣乔治呼吸问卷(SGRQ)评分、COPD评估测试(CAT)评分,治疗前后肺功能指标,治疗前后氧化应激指标以及用药期间不良反应发生情况。结果与治疗前比较,两组患者mMRC评分、SGRQ评分、CAT评分、丙二醛(MDA)水平均呈降低趋势,且观察组降低趋势更明显(P<0.05);与治疗前比较,两组患者的第1 s用力呼气容积(FEV1)、肺活量(FVC)、FEV1/FVC、超氧化物歧化酶(SOD)水平呈升高趋势,观察组患者变化趋势更明显(P<0.05);两组患者用药不良反应比较,差异无统计学意义(P>0.05)。结论老年稳定期COPD患者采用桉柠蒎肠溶软胶囊联合噻托溴铵-奥达特罗联合治疗方式,可改善患者肺功能与临床症状,有助于预后和生存质量的提高,缓解机体氧化应激,且未增加不良反应,安全性佳。
Objective To analyze the effects of the combined treatment of eucalyptol enteric soft capsule combined with tiotropium romide and olodaterol on the respiratory mechanics and prognosis of elderly patients with stable chronic obstructive pulmonary disease(COPD).Methods Selected a total of 70 patients with a total of 70 patients with COPD patients who were included in the standard stable period from March 2022 to March 2023,and divided all patients into control groups and observation groups according to the random digital table method.example.The control group was treated with tiotropium bromide and olodaterol,and patients in the observation group were treated with eucalyptol enteric soft capsule combined with tiotropium bromide and olodaterol.Analyze the treatment effect of the two groups of patients.The evaluation index is the score of patient respiratory difficulties(MMRC),San George Breathing Questionnaire(SGRQ)score,COPD evaluation test(CAT)score,COPD evaluation test(CAT).The adverse reaction occurred during the medication.Results Compared with before treatment,the two groups of patients MMRC,SGRQ,and CAT scores,and the levels of the two aldehydes(MDA)were reduced,and the appointment group reduced the trend more obvious;compared with the treatment before treatment,the 1s 1s of the two groups of patients pierced forced Expressive accumulation(FEV1),lung activity(FVC),FEV1/FVC,super oxide dismissal enzyme(SOD)level is increasing,and the changes in patients in the observation group are more obvious(P<0.05);two groups of patients with adverse medication reactions are compared There is no statistical difference(P>0.05).Conclusion Patients with COPD in the elderly stable period adopt the combined treatment of eucalyptol enteric soft capsule combined with tiotropium bromide and olodaterol to improve the patient's lung function and clinical symptoms,which is conducive to the improvement of prognosis and quality of survival,alleviating the body's oxidation and stress stress The combined medication does not increase adverse reactions and has good safety.
作者
张静
刘华
ZHANG Jing;LIU Hua(Gansu University of Traditional Chinese Medicine,Lanzhou,Gansu 730000;Baiyin City First People's Hospital,Baiyin,Gansu 730900;Gansu Provincial People's Hospital,Lanzhou,Gansu 730000)
出处
《智慧健康》
2025年第10期85-88,共4页
Smart Healthcare
关键词
老年
慢性阻塞性肺疾病
稳定期
桉柠蒎肠溶软胶囊
呼吸力学
预后
Elderly
Chronic obstructive pulmonary disease
Stable period
Eucalyptol enteric soft capsule
Respiratory mechanics
Prognosis
作者简介
张静(1989-),女,汉族,甘肃白银人,本科,主治医师,研究方向:呼吸病学;通信作者:刘华(1962-),女,汉族,甘肃兰州人,本科,主任医师,研究方向:呼吸系统疾病。
