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三种光学干预措施在近视进展控制中的作用——基于一项倾向性评分匹配研究

Analysis of efficacy of three optical interventions for myopia progression control:a propensity-score-matched study
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摘要 目的评估对比儿童配戴多区正向离焦设计镜片(DIMS)、特殊周边离焦设计镜片(PDM)和单焦点镜片(SVL)在真实世界中对儿童青少年近视控制的效果。方法选取2019年7月至2022年6月福建省立医院眼科门诊就诊的6~16岁DIMS配戴者188例,PDM配戴者116例与SVL配戴者373例,均为右眼。采用1:1倾向性评分匹配(PSM)平衡组间混杂变量。比较PSM后各组患者在戴镜前及戴镜后1年等效球镜度(SE)与眼轴长度的进展。结果PSM后共纳入92对DIMS组与PDM组患者,163对DIMS组与SVL组患者以及99对PDM组与SVL组患者。DIMS组患者SE和眼轴长度进展均小于PDM组和SVL组,差异均有统计学意义(均为P<0.05)。PDM组与SVL组患者SE和眼轴长度进展差异均无统计学意义(均为P>0.05)。在年龄亚组分析中,在低龄组(6~<13岁)、高龄组(13~16岁)中,DIMS组患者SE和眼轴长度进展均小于PDM组和SVL组,差异均有统计学意义(均为P<0.05)。低龄组中PDM组患者SE和眼轴长度进展均小于SVL组,差异均有统计学意义(均为P<0.05);而在高龄组中,PDM组与SVL组患者SE和眼轴长度进展差异均无统计学意义(均为P>0.05)。结论DIMS的近视控制效果优于PDM和SVL。在低龄儿童中,PDM近视控制效果优于SVL。 Objective To evaluate the efficacy of myopia progression control over a one-year period for defocus incorporated multiple segments lenses(DIMS),peripheral defocus modifying(PDM)lenes and single vision spectacle lenses(SVL)in a real-world cohort.Methods A total of 188 cases in the DIMS group,116 cases in the PDM group,and 373 cases in the SVL group,all diagnosed with refractive errors and aged 6-16 years,were enrolled in Department of Ophthalmology,Fujian Provincial Hospital from July 2019 to June 2022.A 1 : 1 propensity score matching(PSM)of covariates was used to balance factors between the groups.The changes in spherical equivalent(SE)and axial length(AL)in each patient before and 1 year after wearing glasses were compared without other interventions.The myopia control effects of different groups were compared through the changes in SE and AL.Results After PSM,92 cases were matched between DIMS group and PDM group,163 cases were matched between DIMS group and SVL group,and 99 cases were matched between PDM group and SVL group.The changes in SE and AL in the DIMS group were less than those in the PDM and SVL groups,with statistically significant differences(all P<0.05).However,there were no statistically significant differences in the changes in SE and AL between the PDM and SVL groups(all P>0.05).In the age subgroup analysis,in the younger age group(6~<13)and the older age group(13~16)the changes in SE and AL in the DIMS group were less than those in the PDM group and SVL group,with statistically significant differences(all P<0.05).In the younger age group,the changes in SE and AL in the PDM group were less than those in the SVL group,with statistically significant differences(all P<0.05);while in older age group,there were no statistically significant differences in the changes in SE and AL between the PDM and SVL groups(all P>0.05).Conclusion The myopia control efficacy of DIMS is superior to that of PDM and SVL.In younger children,the myopia control efficacy of PDM is superior to that of SVL.
作者 王钤君 李瑜敏 董钰玲 许诺 WANG Qianjun;LI Yumin;DONG Yuling;XU Nuo(Shengli Clinical Medical College,Fujian Medical University,Fuzhou 350001,Fujian Province,China;School of Basic Medical Science,Fujian Medical University,Fuzhou 350122,Fujian Province,China;Department of Ophthalmology,Fujian Provincial Hospital,Shengli Clinical Medical College,Fujian Medical University,Fuzhou University Affiliated Provincial Hospital,Fuzhou 350001,Fujian Province,China)
出处 《眼科新进展》 北大核心 2025年第7期562-565,共4页 Recent Advances in Ophthalmology
基金 福建省自然科学基金项目(编号:2023Y9354) 福建医科大学大学生创新创业培训计划项目(编号:JC202303071)。
关键词 近视 眼轴 多区正向离焦 周边离焦 myopia axial length defocus incorporated multiple segments peripheral defocus
作者简介 王钤君(ORCID:0009-0003-3428-0055),男,2003年1月出生,福建龙岩人。研究方向:屈光不正。E-mail:wangqianjun03@163.com;通信作者:许诺(ORCID:0000-0003-2833-9017),男,1985年6月出生,福建福州人,博士,副主任医师,硕士研究生导师。研究方向:屈光不正。E-mail:optnuox@qq.com。
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