摘要
铁离子在人体内分布广泛,参与一系列生化反应.细胞中的铁离子主要以Fe^(2+)与Fe^(3+)的形式存在,对维持细胞正常功能发挥着重要作用.在活细胞还原环境中,细胞内游离铁主要以Fe^(2+)离子形式存在.游离Fe^(2+)可作为芬顿反应催化剂,使细胞内产生活性氧物种(ROS),对细胞造成严重损伤,引起一系列与之相关的疾病.因此,在生理环境中对Fe^(2+)的可视化监测具有必要性,有助于进一步了解疾病的发病机制和进展.近年来,已有一些研究人员致力于设计并合成具有优异光学性能并可用于体内外监测Fe^(2+)的荧光探针.其中,N-氧化物结构的荧光探针凭借其选择性强、灵敏度高及可进行原位实时成像等优势受到了研究人员的广泛关注.针对N-氧化物类Fe^(2+)荧光探针的结构、设计思路、光学性质与应用等方面进行了介绍.
Iron is widely distributed in the human body,participating in numerous biochemical reactions.Iron exists in the forms of Fe^(2+)and Fe^(3+)in cells,playing crucial roles in maintaining normal cellular functions.In the reducing environment of living cells,the labile iron primarily exists in the form of Fe^(2+)ions.The labile Fe^(2+)can serve as a catalyst for the Fenton reaction,generating reactive oxygen species(ROS)within the cell,which can cause severe damage to the cell and lead to a range of related diseases.Therefore,visual monitoring Fe^(2+)in the physiological environment is necessary to contribute to a deeper understanding of the pathogenesis and progression of the disease.In recent years,several researchers have focused on designing and synthesizing fluorescent probes with excellent optical properties that can be used to monitor Fe^(2+)in vivo and in vitro.Among them,the N-oxide-based fluorescence probes have been concerned by researchers because of its advantages of strong selectivity,high sensitivity,and in-situ real-time imaging.The structures,design considerations,optical properties,and applications of N-oxide-based Fe^(2+)fluorescence probes are discussed.
作者
相韩悦
魏少荫
王玉记
肖猱
Xiang Hanyue;Wei Shaoyin;Wang Yuji;Xiao Nao(Engineering Research Center of Endogenous Prophylactic of Ministry of Education,Major Laboratory of Peptide and Small Molecular Drugs,School of Pharmaceutical Sciences,Capital Medical University,Beijing 100069;Pharmacy Department,Beijing Jishuitan Hospital Affiliated to Capital Medical University,Beijing 100035)
出处
《有机化学》
北大核心
2025年第4期1137-1152,共16页
Chinese Journal of Organic Chemistry
基金
首都医科大学培育基金(No.PYZ21023)资助项目。
作者简介
Corresponding author:肖猱.E-mail:xiaonao@ccmu.edu.cn;Corresponding author:王玉记.E-mail:wangyuji@ccmu.edu.cn。
