摘要
中药活性成分在不同类型恶性肿瘤中具有抗肿瘤活性,同时毒副作用较小。然而,多数活性成分的溶解性差、体内稳定性差、代谢快、靶向效率低,严重限制了其在临床中的应用。脂质体负载中药活性成分是一种有效的递药策略。该文对部分典型中药活性成分的抗肿瘤作用作简单介绍总结,综述了脂质体通过表面修饰提高靶向性、改善药动学特征、肿瘤微环境响应释药、联合给药以及联合治疗策略提高活性成分的抗肿瘤作用研究进展,并对目前脂质体载中药活性成分的应用前景进行了讨论。
The active ingredients of traditional Chinese medicine(TCM)have anti-tumor activities in different types of tumors,with less toxic side effects.However,most of the active ingredients of TCM have low solubility,poor in vivo stability,fast metabolism,and low targeting efficiency,severely limiting their clinical application.Liposome-loaded active ingredients of TCM are an effective drug delivery strategy.This review summarized the effects of some typical types of active ingredients in TCM on various tumors,and focused upon the research progress of liposomes in improving the targeting effect,pharmacokinetic characteristics,and tumor microenvironmental response to drug release through surface modification to improve targeting,as well as their combined administration,and combined treatment strategies to improve the anti-tumor effects.The application prospects of liposome-loaded active ingredients of TCM were discussed.
作者
杨堃
刘萍
YANG Kun;LIU Ping(Department of Pharmacy,The 97oth Hospital of the Joint Logistic Support Force of PLA,S Yantai 264000,China)
出处
《中国医院药学杂志》
北大核心
2025年第10期1198-1204,共7页
Chinese Journal of Hospital Pharmacy
关键词
中药活性成分
脂质体
抗肿瘤作用
靶向
联合治疗
active ingredients of traditional Chinese medicine
liposome
anti-tumor effect
targeting
combined treatment
作者简介
杨堃,女,硕士,主管药师,研究方向:药剂学,临床药学;通信作者:刘萍,女,研究生,副主任药师,研究方向:药学,临床药学。
