摘要
椎间盘退变(IDD)以髓核细胞减少、软骨终板炎症、纤维环破裂为病理特点。再生疗法促进椎间正常生理结构的修复一直是研究热点,其中外泌体(Exos)治疗在近些年备受关注。许多研究表明,Exos通过维持细胞外基质稳态、抑制细胞凋亡、抗氧化和抗炎等作用,恢复退变椎间盘的结构和功能特性,发挥治疗IDD的作用。本文综述了不同细胞来源的Exos在IDD治疗领域的研究现状、Exos与各种生物疗法的优劣分析及Exos治疗的未来展望。
Intervertebral disc degeneration(IDD)is characterized pathologically by a reduction in nucleus pulposus cells,inflammation of the cartilaginous endplate,and annulus fibrosus rupture.Regenerative therapies aimed at restoring the normal physiological structure of the intervertebral disc have been a focus of research,with exosome(Exo)therapy receiving considerable attention in recent years.Many studies have shown that Exos exert therapeutic effects on IDD by maintaining extracellular matrix homeostasis,inhibiting cell apoptosis,and exhibiting antioxidant and anti-inflammatory properties,thereby restoring the structural and functional characteristics of degenerated intervertebral discs.This review summarizes the current research status of Exos from different cellular sources in the field of IDD treatment,analyzes the advantages and disadvantages of Exos compared to various biological therapies,and discusses the future prospects of Exo therapy.
作者
黄飞鸿
江华
HUANG Feihong;JIANG Hua(Department of Spinal Surgery and Orthopaedics,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)
出处
《广西医科大学学报》
2025年第3期464-470,共7页
Journal of Guangxi Medical University
基金
国家自然科学基金资助项目(No.82360438)
广西自然科学基金区域高发疾病研究联合专项(No.2024GXNSFDA010043)
广西自然科学基金资助项目(No.2023GXNSFAA026339)。
关键词
外泌体
椎间盘退变
治疗手段
干细胞
exosomes
intervertebral disc degeneration
treatment methods
stem cells
作者简介
通信作者:江华,E-mail:jianghua@gxmu.edu.cn。
