摘要
一氧化氮(NO)是一种具有重要生物学功能的信号分子,参与血管舒张、神经传递、免疫调节等多种生理过程。NO治疗仪作为NO递送的关键设备,通过精确控制气体浓度和释放模式,已在呼吸系统疾病、心血管疾病及肿瘤治疗中展现出独特优势。然而,NO的半衰期极短、浓度依赖性强以及存在潜在毒性等问题,对治疗仪的技术设计和临床应用提出了挑战。本文综述了NO治疗仪的发展历程,涵盖国内外的研究进展、技术结构、分类方式,探讨了当前面临的困境以及未来的发展趋势,旨在为该领域的深入研究提供参考,助力NO治疗仪在医学领域实现更广泛的应用。
Nitric oxide(NO),as a signaling molecule with critical biological functions,is involved in various physiological processes such as vasodilation,neurotransmission,and immune regulation.As a key device for NO delivery,NO therapeutic devices have demonstrated unique advantages in the treatment of respiratory diseases,cardiovascular diseases,and tumors by precisely controlling gas concentration and release patterns.However,challenges in technical design and clinical application arise from NO’s extremely short half-life,strong concentration dependence,and potential toxicity.This paper reviewed the development history of NO therapeutic devices,covering research progress at home and abroad,technical structures,classification methods,and explored current dilemmas and future development trends,aiming to provide a reference for in-depth research in this field and facilitate broader applications of NO therapeutic devices in medicine.
作者
张小四
向思伟
林忠款
郑焜
ZHANG Xiaosi;XIANG Siwei;LIN Zhongkuan;ZHENG Kun(Department of Neonatology,The Children’s Hospital,Zhejiang University School of Medicine,Hangzhou Zhejiang 310057,China;Department of Medical Equipment,The Children’s Hospital,Zhejiang University School of Medicine,Hangzhou Zhejiang 310057,China;National Clinical Research Center for Child Health,Hangzhou Zhejiang 310057,China)
出处
《中国医疗设备》
2025年第6期152-158,共7页
China Medical Devices
基金
浙江省医药卫生科技计划项目(2023KY831)。
关键词
一氧化氮治疗仪
呼吸机
气体生成技术
传感器优化
联合治疗
nitric oxide(NO)therapeutic device
ventilator
gas generation technology
sensor optimization
combined therapy
作者简介
通讯作者:郑焜,高级工程师,主要研究方向为国内外生物医学工程领域的最新发展。邮箱:zhengkun@zju.edu.com。
