摘要
E3泛素连接酶对细胞内蛋白质命运具有重要调控作用。宿主细胞E3泛素连接酶MARCH1蛋白是RING家族成员,在调控宿主细胞免疫识别和免疫应答中具有重要作用。近期研究结果表明,MARCH1在宿主细胞抗病毒感染中发挥重要角色。其抗病毒感染主要有两种模式。一方面,MARCH1通过诱导病毒蛋白质发生泛素化并靶向细胞内途径降解;另一方面,MARCH1可将病毒囊膜糖蛋白滞留在细胞内,进而阻断病毒的组装和感染循环。本文将对宿主MARCH1分子的两种抗病毒感染模式进行阐述,为后续抗病毒研究工作提供参考。
E3 ubiquitin ligase plays an important role in regulation of intracellular proteins translocation.The host cell MARCH1 protein is a member of the E3 ubiquitin RING ligase family and executes crucial function in regulating cellular immuno-recognition and immune responses.Recent researches indicate that MARCH1 molecule also acts actively in cellular immunity against viral infections.At present,there are two typical types of antiviral modes available for MARCH1.On the one hand,MARCH1 recognizes the intracellular terminal sequence of viral proteins 1and induces their ubiquitination,thereby targeting them into the intracellular degradation pathways;on the other hand,MARCH1 retains the viral envelope glycoprotein intracellularly,thereby blocking the viral assembly and the corresponding infection cycles.Here,in this review,we will illustrate the specific antiviral mechanisms of MARCH1 in the two antiviral modes,which should be beneficial for subsequent antiviral researches.
作者
于长清
彭永刚
张贺
李明翔
徐超
张斌
先元华
汤艳东
YU Changqing;PENG Yonggang;ZHANG He;LI Mingxiang;XU Chao;ZHANG Bin;XIAN Yuanhua;TANG Yandong(Engineering Center of Agricultural Biosafety Assessment and Biotechnology,School of Advanced Agricultural Sciences,Yibin Vocational and Technical College,Yibin 644001,China;State Key Laboratory for Animal Disease Control and Prevention,Harbin Veterinary Research Institute,CAAS,Harbin 150069,China;College of Animal and Veterinary Sciences,Southwest Minzu University,Chengdu 610041,China)
出处
《中国动物传染病学报》
北大核心
2025年第2期220-226,共7页
Chinese Journal of Animal Infectious Diseases
基金
宜宾职业技术学院自然科学研究重点项目(ZR22ZD-01)。
作者简介
于长清,副教授,男,主要从事天然免疫抗病毒方面研究;彭永刚,男,副研究员,主要从事兽医传染病防治方面研究;张贺,助理研究员,男,主要从事动物模型研究方面研究;通信作者:汤艳东,E-mail:tangyandong@caas.cn;通信作者:先元华,E-mail:472199917@qq.com。
