摘要
目的 本研究旨在对比分析阿立哌唑与利培酮两种药物在分别联合氯氮平治疗难治性精神分裂症时的疗效及安全性,以期为难治性精神分裂症的临床治疗提供更为有效的用药指导。方法 本研究采用前瞻性随机研究设计,随机选取2022年1月—2024年4月聊城市第四人民医院收治的难治性精神分裂症患者120例。按照不同的治疗方法,将这些患者平均分为对比组(n=60,利培酮联合氯氮平治疗),探究组(n=60,阿立哌唑联合氯氮平治疗)。对比两组再住院率、不良反应发生率、社交功能及临床症状评分。结果 治疗后,探究组患者社交功能优于对比组,临床症状评分低于对比组,差异均有统计学意义(P均<0.05)。在安全性方面,探究组患者的再住院率为5.00%(3/60)、不良反应总发生率为3.33%(2/60),均低于对比组的16.67%(10/60)、13.33%(8/60),差异均有统计学意义(χ^(2)=3.927,4.227;P均<0.05)。结论 阿立哌唑联合氯氮平在治疗难治性精神分裂症的效果较好,不仅降低了患者的临床症状评分,还能够改善患者的社交功能。同时,该联合用药方案的安全性也更高,不良反应总发生率和再住院率均降低。
Objective The purpose of this study was to compare and analyze the efficacy and safety of aripiprazole and risperidone in the treatment of refractory schizophrenia with clozapine,in order to provide more effective medication guidance for the clinical treatment of refractory schizophrenia.Methods 120 patients with refractory schizophrenia admitted to Liaocheng Fourth People's Hospital from January 2022 to April 2024 were randomly selected.According to different treatment methods,these patients were divided into the control group(n=60,risperidone combined with clozapine treatment)and the study group(n=60,aripiprazole combined with clozapine treatment).The rehospitalization rate,incidence of adverse reactions,social function and clinical symptom scores of the two groups were compared.Results After treatment,the social function of the study group was better than that in the control group,the clinical symptom score of the study group was lower than that of the control group,and the differences were statistically significant(all P<0.05).In terms of safety,the rehospitalization rate of patients in the study group was 5.00%(3/60),and the total incidence of adverse reactions was 3.33%(2/60),and which were lower than 16.67%(10/60)and 13.33%(8/60)in the control group,the differences were statistically significant(χ^(2)=3.927,4.227;both P<0.05).Conclusion Aripiprazole combined with clozapine has a better effect in the treatment of refractory schizophrenia,which not only reduces the clinical symptom score of patients,but also improves the social function of patients.At the same time,the safety of the combination regimen was also higher,and the total incidence of adverse reactions and rehospitalization rates were reduced.
作者
王焕明
WANG Huanming(Liaocheng Fourth People's Hospital,Liaocheng,Shandong,252000,China)
出处
《中外医疗》
2025年第9期71-75,共5页
China & Foreign Medical Treatment
作者简介
王焕明(1980-),女,本科,副主任医师,研究方向为精神疾病的药物治疗。
