柴桂龙牡汤联合阿普唑仑治疗失眠伴焦虑抑郁障碍的疗效观察

Clinical Observation on the Efficacy of Chaigui Longmu Decoction Combined with Alprazolam in the Treatment of Insomnia with Anxiety and Depression Disorders

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摘要目的:观察柴桂龙牡汤联合阿普唑仑治疗失眠伴焦虑抑郁障碍的临床疗效。方法:选取2023年3月至2024年12月山东省聊城市第四人民医院诊治的失眠伴焦虑抑郁障碍者100例作为研究对象,根据用药方案分为对照组和观察组,每组50例。对照组给予阿普唑仑治疗,观察组给予柴桂龙牡汤联合阿普唑仑治疗。比较2组疗效,观察中医证候、焦虑与抑郁及睡眠障碍状况变化。结果:观察组总有效率98.00%(49/50),对照组82.00%(41/50),2组总有效率比较差异有统计学意义(P<0.05);观察组治疗后中医证候积分、焦虑与抑郁评分、睡眠障碍评分均低于对照组(P<0.05)。结论:柴桂龙牡汤联合阿普唑仑治疗失眠伴焦虑抑郁障碍临床疗效果更理想确切,可更好地改善身心健康及睡眠质量。 Objective:To observe the clinical efficacy of Chaigui Longmu Decoction combined with alprazolam in the treatment of insomnia with anxiety and depression disorders.Methods:A total of 100 patients with insomnia accompanied by anxiety and depression disorders,treated at The Fourth People′s Hospital of Liaocheng from March 2023 to December 2024,were selected as the study subjects.They were randomly divided into a control group and an observation group,with 50 patients in each group.The control group received alprazolam treatment,while the observation group received Chaigui Longmu Decoction combined with alprazolam.The efficacy of the two groups was compared,and changes in traditional Chinese medicine(TCM)syndrome,anxiety and depression scores,and sleep disorder status were observed.Results:The total effective rate in the observation group was 98.00%(49/50),while the control group had a total effective rate of 82.00%(41/50),and the difference between the two groups was statistically significant(P<0.05).After treatment,the observation group showed significantly lower TCM syndrome scores,anxiety and depression scores,and sleep disorder scores compared to the control group(P<0.05).Conclusion:Chaigui Longmu Decoction combined with alprazolam provides a more favorable clinical outcome in the treatment of insomnia with anxiety and depression disorders and is more effective in improving both physical and mental health,as well as sleep quality.

作者侯晓庞延苹王春燕王红星 HOU Xiao;PANG Yanping;WANG Chunyan;WANG Hongxing(Department of Geriatric Rehabilitation,The Fourth People′s Hospital of Liaocheng,Liaocheng 252000,China;Department of NeurologyⅡ,The Fourth People′s Hospital of Liaocheng,Liaocheng 252000,China;Department of Neurology I,The Fourth People′s Hospital of Liaocheng,Liaocheng 252000,China)

机构地区山东省聊城市第四人民医院老年康复科山东省聊城市第四人民医院神经内科二山东省聊城市第四人民医院神经内科一

出处《世界睡眠医学杂志》 2025年第3期572-574,578,共4页 World Journal of Sleep Medicine

关键词失眠焦虑抑郁障碍睡眠质量柴桂龙牡汤中西医结合疗法 Insomnia Anxiety and depression disorders Sleep quality Chaigui Longmu Decoction Integrated Traditional Chinese and Western Medicine