摘要
为了增强医用镁合金表面羟基磷灰石(HA)涂层的抗菌性能,使用微波水相法在壳聚糖中间层表面制备了银铜共掺HA(AgCuHA)仿生涂层。使用XRD,SEM,EDS,TEM、光学轮廓仪和接触角测定仪分析了AgCuHA仿生涂层的物相、表面形貌、化学组成、晶体结构、表面粗糙度和亲水性;应用平板涂布法和CCK-8法测试了涂层的抗菌性能和细胞活力。结果表明,AgCuHA涂层由富含纳米缺陷的纳米锥自下而上构建,形成一种仿生微/纳米拓扑结构;亲水性仿生涂层不但展现了高抗菌性能,而且可抑制镁合金的快速降解,具有良好细胞相容性。
Aiming at enhancing the antibacterial property of biomedical magnesium alloy with hydroxyapatite coating,silver-copper-codoped hydroxyapatite(AgCuHA)biomimetic coating was prepared on chitosan interlayer.XRD,SEM,EDS,TEM,optical profiler and contact angle tester were applied to analyze the phase,surface morphology,chemical composition,crystal structure,surface roughness and hydrophilicity of the coatings.Spread plate and CCK-8 methods were adopted to test antibacterial property and cell viability of the coatings.The results indicated that AgCuHA coating was constructed by nanodefect-rich nanocones in a bottom-up way,resulting in a kind of biomimetic micro/nano-topography.This hydrophilic biomimetic coating not only showed high antibacterial property,but also inhibited magnesium alloy rapid degradation and demonstrated good cytocompatibility.
作者
王琪
丁秀静
鲍小刚
杨喜月
董博玮
张璐
申偲伯
WANG Qi;DING Xiu-Jing;BAO Xiao-Gang;YANG Xi-Yue;DONG Bo-Wei;ZHANG Lu;SHEN Si-Bo(Hebei Key Laboratory of Active Components and Functions in Natural Products,College of Chemical Engineering,Hebei Normal University of Science and Technology,Qinhuangdao 066004,China;Department of Orthopaedic Spine Surgery,Second Affiliated Hospital of Naval Military Medical University,Shanghai 200003,China)
出处
《现代技术陶瓷》
2025年第1期86-97,共12页
Advanced Ceramics
基金
河北省三三三人才工程资助项目(C20221031)
国家自然科学基金(51802221)
关键词
银铜共掺羟基磷灰石涂层
仿生拓扑结构
微波水相制备
抗菌性能
silver-copper-codoped hydroxyapatite coating
biomimetic topography
microwave aqueous preparation
antibacterial property
作者简介
第一作者:王琪(2001-),女,河北衡水人,硕士研究生。Email:3099002751@qq.com;通信作者:申偲伯(1988-),男,河北秦皇岛人,副教授。Email:ssb3901@hevttc.edu.cn。
