摘要
背景:新型生物材料不仅提供必要的机械支撑,还能促进细胞增殖和分化、诱导骨再生,从而改善治疗效果,为骨再生技术的发展提供了新的视角和方法。目的:通过文献计量学方法可视化分析生物材料在骨再生领域的研究状况及发展前景。方法:在Web of Science核心数据库中,精选了数据库建库至2024-09-24关于骨再生和生物材料领域最具影响力的文献500篇,运用VOSviewer和CiteSpace两款工具进行深入的计量学可视化分析,以揭示该领域的研究趋势和核心文献结果与结论:在所选的500篇文献中,中国和美国在发表论文数量和被引用率方面均占据领先地位,而常江是发文最多的作者,发表文章最多的期刊为Acta Biomaterialia。骨再生和材料学是一个跨学科的研究范畴,涵盖了材料科学、生物医学工程、细胞生物学、分子生物学等多个学科领域。骨修复材料的研究正从传统的生物惰性材料向生物活性材料转变,这些材料不仅提供机械支撑,还能促进细胞增殖和分化,诱导骨再生。合成骨修复材料因丰富的来源、可调节的物理化学特性以及较低的免疫排斥和疾病传播风险,正逐渐替代传统材料,成为临床骨移植手术的首选。研究者们正在不断改进这些材料的生物相容性、仿生特性、骨传导性和骨诱导性,使其更接近天然骨,前沿主要集中在生物活性陶瓷、3D打印、水凝胶、壳聚糖、羟基磷灰石等材料。新型材料在骨再生领域中的作用至关重要,随着材料科学技术的不断进步,这些新型材料在骨再生领域的应用前景非常广阔,有望为骨缺损治疗提供更为有效和个性化的治疗方案。
BACKGROUND:Novel biomaterials not only provide the necessary mechanical support but also promote cell proliferation and differentiation,inducing bone regeneration,thereby improving therapeutic outcomes and offering new perspectives and methods for the development of bone regenerative technologies.OBJECTIVE:To visualize the research status and development prospects of biomaterials in the field of bone regeneration through bibliometric methods.METHODS:A total of 500 of the most influential papers on bone regeneration and biomaterials were selected from the Web of Science Core Collection database from inception to September 24,2024.VOSviewer and CiteSpace tools were used for in-depth bibliometric visualization analysis to reveal the research trends and core literature in this field.RESULTS AND CONCLUSION:Among the selected 500 papers,China and the United States were in a leading position in terms of the number of published papers and citation rates,with Chang Jiang being the most prolific author and the journal Acta Biomaterialia publishing the most articles.Bone regeneration and material science is an interdisciplinary research field,covering various disciplines including materials science,biomedical engineering,cell biology,and molecular biology.Research on bone repair materials is shifting from traditional bioinert materials to bioactive materials,which not only provide mechanical support but also promote cell proliferation and differentiation,inducing bone regeneration.Synthetic bone repair materials are gradually replacing traditional materials,becoming the preferred choice for clinical bone graft surgery due to their abundant sources,adjustable physicochemical properties,and lower risks of immune rejection and disease transmission.Researchers are continuously improving the biocompatibility,biomimetic properties,osteoconductivity,and osteoinductivity of these materials to make them closer to natural bone.The frontiers are mainly focused on bioactive ceramics,3D printing,hydrogels,chitosan,hydroxyapatite,and other materials.New materials play a vital role in the field of bone regeneration.With the continuous advancement of materials science and technology,the application prospects of these new materials in the field of bone regeneration are very broad,and they are expected to provide more effective and personalized treatment options for bone defect treatment.
作者
姜侃
阿力木江·阿不都肉苏力
沙拉依丁·艾尔西丁
艾克拜尔江·艾赛提
库提鲁克·守克尔
艾克热木江·木合热木
Jiang Kan;Alimujiang·Abudourousuli;Shalayiding·Aierxiding;Aikebaierjiang·Aisaiti;Kutiluke·Shoukeer;Aikeremujiang·Muheremu(Department of Orthopedics,the Sixth Affiliated Hospital of Xinjiang Medical University,Urumqi 830002,Xinjiang Uygur Autonomous Region,China;Key Laboratory of Orthopedic Regenerative Medicine,the Sixth Affiliated Hospital of Xinjiang Medical University,Urumqi 830002,Xinjiang Uygur Autonomous Region,China)
出处
《中国组织工程研究》
北大核心
2026年第2期528-536,共9页
Chinese Journal of Tissue Engineering Research
作者简介
第一作者:姜侃,男,1971年生,新疆维吾尔自治区乌鲁木齐市人,汉族,副教授,主要从事骨再生相关研究;并列第一作者:阿力木江·阿不都肉苏力,男,2000年生,新疆维吾尔自治区乌鲁木齐市人,新疆医科大学第六附属医院关节外科在读硕士,主要从事骨缺损和骨再生相关研究,https://orcid.org/0009-0008-6254-4800;通讯作者:艾克热木江·木合热木,博士,主任医师,副教授,硕士生导师,新疆医科大学第六附属医院,骨科,骨科再生医学重点实验室,新疆维吾尔自治区乌鲁木齐市830002,https://orcid.org/0000-0002-1690-9644。
