摘要
目的:分析1例聚多卡醇致儿童面部皮肤肿胀坏死不良反应,并复习相关不良反应文献,总结聚多卡醇不良反应的发生特点、影响因素及防治要点,为临床安全合理使用聚多卡醇提供参考。方法:报道1例因面部血管畸形接受聚多卡醇治疗后出现面部皮肤肿胀坏死患儿的临床资料,以“聚多卡醇”“不良反应”等作为关键词,全面检索国内外权威数据库如中国知网、万方、PubMed等自建库起至2025年3月1日的相关文献报道进行文献复习。结果:本例患儿在用药后出现面部皮肤肿胀,并进展为坏死。文献复习发现,聚多卡醇导致儿童不良反应多样,除皮肤肿胀坏死外,对神经系统、心血管系统、呼吸系统等都可能有影响。不良反应发生与给药途径、用药剂量及医师操作手法紧密相关。结论:临床应用聚多卡醇时,需严格掌握适应证,精准控制用药剂量与给药途径,密切监测用药后反应。一旦发生不良反应,应及时采取有效干预措施,以降低严重不良反应发生率,保障患儿用药安全。
Objective:To analyze the adverse drug reaction of facial skin swelling and necrosis induced by polydocanol in a child,and to summarize the occurrence characteristics,influencing factors,prevention and treatment points of polydocanol-induced adverse drug reaction by reviewing the related literature,so as to provide reference for the safe and rational use of polydocanol in clinic.Methods:Clinical data of a child with facial skin swelling and necrosis after receiving treatment with polidocanol due to facial vascular malformation were reported.Taking“polykadol”“adverse drug reactions”as key words,comprehensive literature review was performed by retrieving relevant literature from authoritative databases at home and abroad such as CNKI,Wanfang,PubMed from the database establishment to Mar.1st,2025.Results:The child developed facial skin swelling and progressed to necrosis after medication.Literature review indicated that polidocanol could cause various adverse drug reactions in children,in addition to skin swelling and necrosis,polydocanol may affect the nervous system,cardiovascular system and respiratory system.The occurrence of adverse drug reaction was closely related to the route of administration,the dosage of medication and the operation techniques of clinicians.Conclusion:When using polidocanol for clinical treatment,it is necessary to strictly control the indications,accurately control the dosage and route of administration,and closely monitor the reactions after medication.In case of adverse drug reactions,effective intervention measures should be taken in time to reduce the incidence of severe adverse drug reactions and ensure the medication safety in children.
作者
宗静
李双
严爱花
谢启兵
普明
李惠英
Zong Jing;Li Shuang;Yan Aihua;Xie Qibing;Pu Ming;Li Huiying(Kunming Children’s Hospital,Kunming 650228,China)
出处
《儿科药学杂志》
2025年第6期47-49,共3页
Journal of Pediatric Pharmacy
关键词
硬化治疗
聚多卡醇
肿胀坏死
sclerotherapy
polidocanol
swelling and necrosis
作者简介
宗静(1987.07-),女,硕士,主管药师,主要从事医院药学工作,E-mail:1040734250@qq.com。;通信作者:李惠英(1980.04-),女,硕士,主任药师,主要从事医院药学工作,E-mail:1819971603@qq.com。
