生长抑素联合泮托拉唑治疗急性上消化道出血患者的效果

Effects of Somatostatin combined with Pantoprazole in treatment of patients with acute upper gastrointestinal bleeding

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摘要目的:观察生长抑素联合泮托拉唑治疗急性上消化道出血患者的效果。方法:回顾性分析2022年6月至2024年6月该院收治的84例急性上消化道出血患者的临床资料,依据治疗方法不同将其分为对照组、研究组各42例。对照组采用泮托拉唑治疗,研究组在对照组治疗基础上联合生长抑素治疗,比较两组疾病相关指标(出血量、止血时间、住院时间)水平,治疗前后血常规指标(红细胞计数、血红蛋白)水平、凝血功能指标(D-二聚体、纤维蛋白原)水平、疾病严重程度[牛津急性疾病严重程度(OASIS)]评分,以及不良反应发生率。结果:研究组出血量少于对照组,止血时间、住院时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组红细胞计数、血红蛋白水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组D-二聚体水平均低于治疗前,且研究组低于对照组,两组纤维蛋白原水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组OASIS评分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:生长抑素联合泮托拉唑治疗急性上消化道出血患者可提高血常规指标水平,改善凝血功能指标与疾病相关指标水平,以及降低疾病严重程度的效果优于单纯泮托拉唑治疗。 Objective:To observe effects of Somatostatin combined with Pantoprazole in treatment of patients with acute upper gastrointestinal bleeding.Methods:The clinical data of 84 patients with acute upper gastrointestinal bleeding admitted to the emergency department of this hospital from June 2022 to June 2024 were retrospectively analyzed.According to different treatment methods,they were divided into control group and study group,42 cases in each group.The control group was treated with Pantoprazole,while the study group was treated with Somatostatin on the basis of that of the control group.The levels of disease-related indexes(amount of bleeding,hemostasis time,hospitalization time),blood routine indexes(red blood cell count,hemoglobin)and coagulation function indexes(D-dimer,fibrinogen),the disease severity[Oxford acute severity of illness score(OASIS)]score,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The amount of bleeding in the study group was less than that in the control group,the hemostasis time and the hospitalization time were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the red blood cell counts and the hemoglobin levels in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of D-dimer in the two groups were lower than those before the treatment,and that in the study group was lower than that in the control group;the fibrinogen levels of the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;and the differences were statistically significant(P<0.05).The OASIS scores of the two groups were lower than those before the treatment,that in the study group was lower than that in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Somatostatin combined with Pantoprazole in the treatment of the patients with acute upper gastrointestinal bleeding can improve the levels of blood routine indexes,improve the levels of coagulation function indexes and disease-related indexes,and reduce the severity of the disease.Moreover,it is superior to simple Pantoprazole treatment.

作者雷尊榜袁佳勇何琴 LEI Zunbang;YUAN Jiayong;HE Qin(Zheng’an County People’s Hospital,Emergency Department,Zunyi 563400 Guizhou,China;Zheng’an County People’s Hospital,Intensive Care Unit,Zunyi 563400 Guizhou,China)

机构地区正安县人民医院急诊科正安县人民医院重症监护室

出处《中国民康医学》 2025年第10期55-57,67,共4页 Medical Journal of Chinese People’s Health

关键词急性上消化道出血生长抑素泮托拉唑血常规凝血功能疾病严重程度不良反应 Acute upper gastrointestinal bleeding Somatostatin Pantoprazole Blood routine Coagulation function Severity Adverse reaction

分类号 R573.2 [医药卫生—消化系统]

作者简介雷尊榜(1979.11-),男,仡佬族,贵州遵义人,本科,副主任医师,研究方向为急诊医学。