摘要
目的探究参乌益肾片联合连续性静脉-静脉血液透析滤过(continuous veno-venous hemodiafiltration,CVVHDF)治疗慢性肾衰竭(chronic renal failure,CRF)的临床效果及对患者肾功能指标、炎症因子水平的影响。方法采用倾向性得分匹配及前瞻性研究的方法,收集2021年10月—2024年4月接受治疗的155例CRF住院患者的临床资料进行研究,采用CVVHDF进行治疗者85例,采用参乌益肾片联合CVVHDF治疗者70例,按照1∶1最邻近匹配法匹配,分成单一组45例、联合组45例。比较2组患者的治疗效果、肾功能指标、炎性因子水平和预后情况。结果治疗后,2组的急性生理学和慢性健康状况评价Ⅱ(acute physiology and chronic health evaluationⅡ,APACHEⅡ)得分、血清肌酐(serum creatinine,SCr)、血尿素氮(blood urea nitrogen,BUN)、白细胞介素-6(interleukin-6,IL-6)、C反应蛋白(C-reactive protein,CRP)、降钙素原(procalcitonin,PCT)、序贯器官衰竭评分(sequential organ failure assessment,SOFA)均降低,且联合组的各项指标均明显更低(P<0.05);治疗后,2组的肾小球滤过率(glomerular filtration rate,GFR)均升高,且联合组的升高更明显(P<0.05)。结论参乌益肾片联合CVVHDF能够有效提高CRF患者的临床疗效,改善肾功能指标,降低炎症因子水平。
Objective To explore the effect of Shenwu Yishen Tablets combined with continuous veno-venous hemodiafiltration(CVVHDF)for chronic renal failure(CRF)treatment and its influence on renal function index and inflammatory factor level in patients.Methods The clinical data of 155 inpatients with CRF who received treatment in our hospital from October 2021 to April 2024 were collected by using propensity score matching and prospective study.A total of 85 patients received CVVHDF alone,while 70 patients received Shenwu Yishen Tablets in combination with CVVHDF.Using a 1∶1 matching ratio,45 cases were matched in each group by the nearest neighbor matching method,forming a single-treatment group and a combination-treatment group.The treatment effect,renal function indices,inflammatory factor level and prognosis were compared between the 2 groups.Results After treatment,acute physiology and chronic health evaluationⅡ(APACHEⅡ)score,serum creatinine(SCr),blood urea nitrogen(BUN),interleukin-6(IL-6),C reactive protein(CRP),procalcitonin(PCT),and sequential organ failure assessment(SOFA)of the 2 groups all decreased,and all indicators in the combinination group were significantly lower compared with the single-treatment group.(P<0.05).After treatment,the glomerular filtration rate(GFR)was increased in both groups,and the increase was more significant in the combined group(P<0.05).Conclusion Shenwu Yishen Tablets combined with CVVHDF can effectively improve the clinical efficacy,improve renal function indicees and reduce the level of inflammatory factors in patients with CRF.
作者
李建军
闫俊慧
孙迎春
刘育硕
杨再波
LI Jianjun;YAN Junhui;SUN Yingchun;LIU Yushuo;YANG Zaibo(Department of Nephrology,Qinhuangdao Hospital of Peking University Third Hospital,Qinhuangdao 066000,China)
出处
《西北药学杂志》
2025年第3期221-225,共5页
Northwest Pharmaceutical Journal
基金
秦皇岛市重点研发计划科技支撑项目(编号:202101A035)。
关键词
慢性肾衰竭
参乌益肾片
连续性静脉-静脉血液透析滤过
肾功能
炎性因子
chronic renal failure
Shenwu Yishen Tablets
continuous venovenous hemodiafiltration
renal function
inflammatory factors
