摘要
目的:运用关联规则和熵聚类算法,分析《中华人民共和国卫生部药品标准·中药成方制剂》(以下简称《中药成方制剂》)中含甘草治疗咳嗽的中成药组方规律及新方发现。方法:收集《中药成方制剂》中含甘草及甘草提取物治疗咳嗽的成方制剂,运用中医传承辅助平台V2.5对用药、性味归经及主治证候等进行频次统计及组方规律分析。结果:含甘草及甘草提取物治疗咳嗽的成方制剂共197首,用药性寒、温、平均居多,归肺经、胃经、脾经居多。高频次证候为痰浊蕴肺证、痰热蕴肺证、风寒袭肺证;其高频药物组合为甘草-苦杏仁、甘草-桔梗、甘草-陈皮;并产生治疗咳嗽新方8个。结论:甘草为治疗咳嗽的良药。甘草在临床应用中广泛用于治疗咳嗽及相关疾病,主要以三拗汤、麻杏石甘汤为基础方;含甘草治疗咳嗽的成方制剂最常用于治疗痰浊蕴肺证、痰热蕴肺证、风寒袭肺证等。该研究通过数据分析客观地呈现了含甘草治疗咳嗽成方制剂的组方规律,为甘草的临床应用及研究提供参考。
Objective:To analyze the prescription regularity of Chinese patent medicines and discovery of new formulas containing Gancao for the treatment of cough in the Pharmaceutical Standard of the Ministry of Health of the People's Re⁃public of Chinese Patent Medicines(hereinafter referred to as Chinese Patent Medicines)by using association rules and entropy clustering algorithms.Methods:The compound preparations containing Gancao and Gancao extract in treating cough in Chinese Patent Medicines were collected,and the Traditional Chinese Medicine Inheritance Auxiliary Platform V2.5 was used to analyze the frequency statistics and prescription regularity of medication,nature,taste,channel tropism and indications.Results:A total of 197 compound preparations containing Gancao and Gancao extract were used for the treatment of cough.The herbs were mainly cold,warm and mild,and mainly entered the lung meridian,stomach meridian and spleen meridian.The high-frequency syndromes were phlegm-turbidity accumulated in the lung,phlegm-heat accumulated in the lung,and wind-cold affecting the lung.High-frequency drug combinations were Gancao-Kuxingren,Gancao-Jiegeng,and Gancao-Chenpi.8 new formulas were generated for the treatment of cough.Conclusion:Gancao is a good remedy for cough.In clinical practice,Gancao is widely used in the treatment of cough and related diseases,mainly based on San'ao Decoction and Maxing Shigan Decoction.The prescription preparations containing Gancao for the treatment of cough are most commonly used to treat the syndromes of phlegm-turbidity accumulated in the lung,phlegm-heat accumulated in the lung and wind-cold affecting the lung.This study objectively presents the prescription regularity of compound preparations containing Gancao for the treatment of cough through data analysis,which provides a reference for the clinical application and research of Gancao.
作者
姬洁莹
吕建军
张妤
Ji Jieying;Lv Jianjun;Zhang Yu(Department of Traditional Chinese Medicine,Shanxi Vocational College of Pharmacy,Taiyuan Shanxi 030001)
出处
《山西中医药大学学报》
2025年第3期243-247,共5页
Journal of Shanxi University of Chinese Medicine
基金
山西省中医药管理局科研课题(2024ZYYB056)
山西药科职业学院校级课题(2023110)。
关键词
甘草
咳嗽
中医传承辅助平台
组方规律
Gancao
cough
Traditional Chinese Medicine Inheritance Auxiliary Platform
prescription regularity
作者简介
姬洁莹,硕士,讲师,Email:jijieying@126.com。
