摘要
目的:优化滑石粉炒牛鞭的炮制工艺,建立滑石粉炒牛鞭饮片的质量标准。方法:在充分的文献调研和预试验基础上,采用L934正交试验以外观性状、粉碎率和浸出物含量作为综合评价指标优选滑石粉用量、炒制温度和炒制时间的最佳工艺参数,采用实验室放大试制和工业化中试生产相结合验证最优炮制工艺;建立滑石粉炒牛鞭饮片的鉴别方法,测定16批炮制品的水分、灰分、浸出物和总游离氨基酸含量。结果:滑石粉炒牛鞭最优炮制工艺为:取待炮制品重量2倍的滑石粉置炒制容器内,180℃炒至滑利状态时,投入牛鞭段(段长1.5 cm),炒药机转速9 r/min,炒制约25 min,炒至表面松泡鼓起、酥脆,取出,筛去滑石粉,放凉;拟制定滑石粉炒牛鞭水分不得高于15%,总灰分不得高于10%,酸不溶性灰分不得高于3%,浸出物不得低于15%,总游离氨基酸不得低于15 mg/g。结论:所优化的炮制工艺适宜工业化生产要求,拟建立的饮片质量标准有助于规范饮片企业炮制工艺,提高临床用药疗效和安全性。
Objective:To optimize the processing technology of cattle penises stir-fried with talcum powder and establish quality standards for the cattle penises stir-fried with talcum powder decoction pieces.Methods:Based on thorough literature research and preliminary trials,an L9(34)orthogonal test was conducted with appearance characteristics,comminution rate,and extract content as comprehensive evaluation indicators to optimize the optimal process parameters for talcum powder dosage,stir-frying temperature and stir-frying time.The optimal processing technology was validated through a combination of laboratory-scale trial production and industrial-scale pilot production.The identification method for cattle penises stir-fried with talcum powder decoction pieces was established,and the moisture,ash,extract and total free amino acid contents of 16 batches of processed products were determined.Results:The optimal processing technology of cattle penises stir-fried with talcum powder was as follows:talcum powder equivalent to twice the weight of the cattle penises to be processed was placed into the stir-frying container,heated to a smooth state at 180℃,and then cattle penises segments(1.5 cm in length)were added.They were stir-fried for approximately 25 minutes at a stir-frying machine speed of 9 r/min until the surface became loose,puffy,and crisp.They were then removed,and the talcum powder was sieved out,after which they were allowed to cool.It was proposed that the water content of cattle penises stir-fried with talcum powder shall not be higher than 15%,the total ash content shall not be higher than 10%,the acid-insoluble ash content shall not be higher than 3%,the extract shall not be lower than 15%,and the total free amino acid shall not be lower than 15 mg/g.Con⁃clusion:The optimized processing technology is suitable for industrial production requirements.The proposed quality standards for the decoction pieces will help standardize the processing technology in decoction pieces enterprises and improve the efficacy and safety of clinical medication.
作者
王轹文
赵莉美
石云云
沈薇
王双
鲁文慧
Wang Liwen;Zhao Limei;Shi Yunyun;Shen Wei;Wang Shuang;Lu Wenhui(School of Pharmacy,Changchun University of Chinese Medicine,Changchun Jilin 130117)
出处
《山西中医药大学学报》
2025年第4期411-417,共7页
Journal of Shanxi University of Chinese Medicine
基金
吉林省中药材标准及中药饮片炮制规范项目(JLPZGF-2020-050
JLPZGF-2020-051)
吉林省教育厅科技项目(JJKH20241087KJ)
吉林省大学生创新创业项目(S202410199042
S202210199070)
吉林省科技发展计划项目(YDZJ202501ZYTS209)。
关键词
牛鞭
滑石粉炒
水分
灰分
浸出物
cattle penises
stir-fried with talcum powder
water content
ash content
extract
作者简介
王轹文,Email:2429352759@qq.com;通讯作者:鲁文慧,硕士,副教授,Email:309572842@qq.com。
