摘要
体外膜肺氧合(ECMO)为危重症患者提供重要体外生命支持,其核心部件氧合膜微孔聚丙烯(PP)膜气透性能好,但微孔存在易漏血的风险;而聚-4-甲基-1-戊烯(PMP)非对称膜制备困难,且两种材料本身疏水,存在血液相容性差等问题。利用亲水、生物相容性好且富含羟基的层状双氢氧化物(LDH)改性聚三氟丙基甲基硅氧烷(PTFPMS),制备了含有LDH-PTFPMS致密分离层的LDH-PTFPMS/PEI复合膜,并研究了LDH改性对膜形貌结构、膜气透性及血液相容性等的影响。结果表明,LDH的加入促进了CO_(2)在膜中的渗透率,与原PTFPMS/PEI膜相比,常压(0.1 MPa)下,4%LDH-PTFPMS/PEI膜的CO_(2)渗透率较原膜提高近50%,且提升了膜的抗蛋白吸附及血小板黏附性能,其中BSA蛋白吸附量降低了21%。
Extra-corporeal membrane oxygenation(ECMO)provides vital extracorporeal life support for critically ill patients.The main commercial oxygenating membrane,core component of ECMO,microporous polypropylene(PP)exhibits good gas permeability but easy blood leakage because of the micropores,while poly(4-methyl-1-pentene)(PMP)shows great difficulty in synthesis,and the hydrophobicity of both membranes often leads to poor blood compatibility.In this research,matrix mixed membranes LDH-PTFPMS/PEI,with the hydrophobic PTFPMS modified with the hydrophilic,bio-compatible and hydroxyl-group rich layered double hydroxide(LDH)as the dense functional separational layer and the microporous PEI membrane as the supporting layer,was synthesized,characterized for their structure as well as morphology,and evaluated for their performance in gas transfer and blood compatibility.The results showed that the addition of LDH promoted the permeability of CO_(2)in the membrane.Compared with the original PTFPMS/PEI membrane,the CO_(2) permeability of the 4%LDH-PTFPMS/PEI membrane increased by nearly 50%under normal pressure(0.1 MPa),and the membranes anti-protein adsorption and platelet adhesion properties were improved,among which BSA protein adsorption was reduced by 21%.
作者
王晓琨
廖泽林
武俊良
陈星宇
于奕菲
贺高红
张秀娟
WANG Xiaokun;LIAO Zelin;WU Junliang;CHEN Xingyu;YU Yifei;HE Gaohong;ZHANG Xiujuan(State Key Laboratory of Fine Chemicals,Frontiers Science Center for Smart Materials Oriented Chemical Engineering,School of Chemical Engineering,Dalian University of Technology,Dalian 116024,Liaoning,China;State Key Laboratory of Fine Chemicals,School of Chemical Engineering,Ocean and Life Science,Dalian University of Technology,Panjin 124000,Liaoning,China;Leicester International Institute,Dalian University of Technology,Panjin 124000,Liaoning,China;R&D Center of Membrane Science and Technology,School of Chemical Engineering,Dalian University of Technology,Dalian 116024,Liaoning,China;Pulmonary and Critical Care Medicine,Affiliated Zhongshan Hospital of Dalian University,Dalian 116001,Liaoning,China)
出处
《化工学报》
北大核心
2025年第4期1800-1808,F0004,共10页
CIESC Journal
基金
国家自然科学基金创新群体项目(22021005)
辽宁省自然科学基金项目(2023-MS-114)。
作者简介
通信作者:贺高红(1966-),女,教授,hgaohong@dlut.edu.cn;通信作者:张秀娟(1978-),女,副教授,xiujuanzhang@dlut.edu.cn;第一作者:王晓琨(1982-),女,博士研究生,287057159@qq.com。
