摘要
目的探讨眼肌前庭诱发肌源性电位(ocular vestibular evoked myogenic potential,oVEMP)和单边离心主观视觉垂直线(unilateral centrifugation subjective visual vertical,UC-SVV)检测在不同临床分期梅尼埃病(Meniere’s disease,MD)患者椭圆囊功能评估中的作用。方法选择山东省耳鼻喉医院2019年7月至2021年9月收治的97例单侧MD患者。所有患者均行oVEMP、UC-SVV检查和纯音听阈测试。根据临床分期将MD分为1、2、3、4期,其中1、2期定义为早期,3、4期定义为晚期。比较不同分期MD患者椭圆囊功能检测结果(oVEMP异常率、UC-SVV异常率和oVEMP+UC-SVV异常率)。采用Spearman相关性分析评价椭圆囊功能和临床分期的相关性。结果97例MD患者中,oVEMP异常率为66.0%(64/97),UC-SVV异常率为55.7%(54/97)。早期MD患者oVEMP异常率和o VEMP+UC-SVV异常率低于晚期患者(P<0.05),两组UC-SVV异常率差异无统计学意义。1期患者o VEMP+UC-SVV异常率低于2期患者(P<0.05),两期患者oVEMP和UC-SVV异常率差异无统计学意义;3期和4期患者3项指标差异均无统计学意义。Spearman相关性检验结果显示,oVEMP异常率(r=0.336,P=0.001)、oVEMP+UC-SVV异常率(r=0.301,P=0.003)与临床分期弱正相关,UC-SVV异常率与临床分期无相关性(r=0.022,P=0.832)。结论o VEMP和UC-SVV检查可用于评估不同临床分期MD患者的椭圆囊功能,两者联合有助于早期(1、2期)MD诊断。
Objective To explore the role of ocular vestibular evoked myogenic potential(oVEMP)and unilateral centrifugation subjective visual vertical(UC-SVV)tests in evaluating the utricular function of patients with Meniere’s disease(MD)at different clinical stages.Methods A total of 97 unilateral MD patients at Shandong Provincial ENT Hospital from July 2019 to September 2021 were selected.All patients underwent oVEMP,UC-SVV,and pure tone audiometry tests.MD patients were classified into clinical stages 1,2,3,and 4,with stages 1 and 2 defined as early stage and stages 3 and 4 as late stage.The results of utricular function tests(abnormal rates of oVEMP,UC-SVV,and oVEMP+UC-SVV)were compared among patients at different stages.Spearman correlation analysis was used to evaluate the correlation between utricular function and clinical staging.Results Among the 97 MD patients,the abnormal rate of oVEMP was 66.0%(64/97),and the abnormal rate of UC-SVV was 55.7%(54/97).The abnormal rates of oVEMP and oVEMP+UC-SVV in early-stage patients were significantly lower than those in late-stage patients(P<0.05),while the difference in UC-SVV abnormal rates between the two groups was not statistically significant.Intra-group comparisons showed that the abnormal rate of oVEMP+UC-SVV in stage 1 patients was significantly lower than that in stage 2 patients(P<0.05),without significant difference in the other indices.There were no significant differences among the three indices in stages 3 and 4 patients.Spearman correlation test results indicated that the abnormal rate of oVEMP(r=0.336,P=0.001)and the abnormal rate of oVEMP+UC-SVV(r=0.301,P=0.003)were weakly positively correlated with clinical staging,while there was no correlation between the abnormal rate of UC-SVV and clinical staging(r=0.022,P=0.832).Conclusions Both oVEMP and UC-SVV tests can assess utricular function in MD patients at different clinical stages.Their combination is helpful of early-stage(stages 1 and 2)MD diagnosis.
作者
李远令
李霄飞
宋永栋
吕亚峰
陈月玲
张道宫
LI Yuanling;LI Xiaofei;SONG Yongdong;LÜYafeng;CHEN Yueling;ZHANG Daogong(Shandong University,Department of Vertigo,Shandong Provincial ENT Hospital,Jinan 250022,Shandong,China)
出处
《中国临床医学》
2025年第2期171-176,共6页
Chinese Journal of Clinical Medicine
基金
国家自然科学基金青年项目(82101226,82401364)。
关键词
梅尼埃病
椭圆囊
临床分期
眼肌前庭诱发肌源性电位
单边离心主观视觉垂直线
Meniere’s disease
utricle
clinical staging
ocular vestibular evoked myogenic potential
unilateral centrifugation subjective visual vertical
作者简介
李远令,技师.E-mail:18753101853@163.com;通信作者:陈月玲.Tel:0531-83086536,E-mail:ameng_72@163.com;通信作者:张道宫.E-mail:zhangdaogong1978@163.com。
